Leishmaniasis – Cannabis THC : CBD Ratios

Leishmaniasis Research Dashboard

6

Primary Studies

2

Related Studies

8

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

0

Animal studies

6

Laboratory studies

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CannaKeys has 8 studies associated with Leishmaniasis.

Here is a small sampling of Leishmaniasis studies by title:


Components of the Leishmaniasis Research Dashboard

  • Dosing information available for Leishmaniasis
  • Chemotype guidance for treating Leishmaniasis with cannabis
  • Synopsis of cannabis research for Leishmaniasis
  • Individual study details for Leishmaniasis

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Overview - Leishmaniasis

Description of Leishmaniasis

Leishmaniasis is a parasitical infection spread by sandflies. It is a significant health problem all over the world. Hundreds of millions of people (as well as animals) in nearly 100 tropical, sub-tropical, and Southern European countries are at risk. Occasional occurrences in the U.S. have been reported from the southern states of Texas and Oklahoma. It is estimated that more than 10 million people are currently suffering from the disease, and new infection rates are in the 2 million range. Making the situation worse, global warming trends have led to the spread of sandfly territory. The disease appears in three distinct forms. Cutaneous leishmaniasis causes open skin sores at the bite site which may spread. The mucosal form produces ulcer formation on mucus membranes such as the mouth, nose, or throat. And, finally the worst form, visceral leishmaniasis affects internal organs such as the spleen, liver, and bone marrow for example. The third form can be fatal. Pharmaceutical treatment of infected humans relies on pentavalent antimonials, amphotericin B, or pentamidine which are expensive and carry the risk of severe adverse reactions. In addition, the parasite is quickly developing a resistance to these drugs.

Disease Classification

Condition: Leishmaniasis
Disease Family: Infectious Disease (Parasite)
Organ System: Integumentary System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B55

Leishmaniasis Symptoms:

Open skin sores, mouth ulcers, pain, enlarged spleen and liver, swollen lymphs, fever, anemia

Also known as:

Cutaneous Leishmaniasis, Visceral Leishmaniasis, Mucocutaneous Leishmaniasis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.