Herpes – Cannabis THC : CBD Ratios

Herpes Research Dashboard

10

Primary Studies

1

Related Studies

11

Total Studies

Clinical Studies

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

0

Animal studies

9

Laboratory studies

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CannaKeys has 11 studies associated with Herpes.

Here is a small sampling of Herpes studies by title:


Components of the Herpes Research Dashboard

  • Dosing information available for Herpes
  • Chemotype guidance for treating Herpes with cannabis
  • Synopsis of cannabis research for Herpes
  • Individual study details for Herpes

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Overview - Herpes

Description of Herpes

Herpes simplex is a common virus that belongs to the same family as the chicken pox virus. There are currently eight known herpes viruses. According to orthodox medicine, all herpes viruses can exist in the body without any outward sign or symptom until a period of depressed immunity suddenly results in an outbreak. Oral herpes (cold sores or fever blisters) called HSV-I usually appears above the waist, in contrast to genital herpes (HSV-II). While HSV I and II are relatively benign physically, they often take a profound toll on the patient's emotional well-being. No orthodox cure exists. A common allopathic treatment to manage herpes is Zovirax (acyclovir). Side effects may include nausea and/or vomiting, diarrhea, dizziness, anorexia, fatigue, swelling of the skin, skin rashes, leg pains, sore throat, and paresthesia (feeling of numbness). A month's supply for the maximum recommended dose costs about $870 (2015).

Disease Classification

Condition: Herpes
Disease Family: Infectious Disease (Viral)
Organ System: Integumentary System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B00

Herpes Symptoms:

Itching, irritation, reddness, swelling, pain, small blister formation, cluster blisters, blister rupture, crust/scab formation

Also known as:

HSV, Herpesviral Infections, Herpes Simplex, Eczema herpeticum,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.