Hemodialysis – Cannabis THC : CBD Ratios

Hemodialysis Research Dashboard

2

Primary Studies

1

Related Studies

3

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

0

Animal studies

1

Laboratory studies

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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 3 studies associated with Hemodialysis.

Here is a small sampling of Hemodialysis studies by title:


Components of the Hemodialysis Research Dashboard

  • Dosing information available for Hemodialysis
  • Chemotype guidance for treating Hemodialysis with cannabis
  • Synopsis of cannabis research for Hemodialysis
  • Individual study details for Hemodialysis

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Overview - Hemodialysis

Description of Hemodialysis

The term hemodialysis refers to the mechanical process of using a filtration device to mimic the function of the kidneys to balance, cleanse and remove waste, solutes, or other no longer needed matter from the blood. Kidney failure (aka acute/chronic kidney disease) mean the organs are no longer working. Since the kidney is a filter organ reduction or cessation of filtration will produce a back-up of waste products. Acute versions can be triggered by trauma (e.g. large surface area burns), reduced renal blood supply (e.g. blockage of artery), or blocked renal pathways (e.g. cancer). Causes for chronic kidney failure may include hypertension, kidney disease, or diabetes for example. Orthodox treatment for both depend on their underlying causes and severity of symptom presentation. End-stage kidney failure will require hemodialysis or a transplant.

Disease Classification

Condition: Hemodialysis
Disease Family: End Stage Kidney Disease
Organ System: Urinary System
ICD-10 Chapter: Factors Influencing Health Status and Contact with Health Services
ICD-10 Code: Z99.2

Hemodialysis Symptoms:

Inefficient kidney function, too little urine, build-up of waste (e.g. urea, creatine, potassium), excess water, fluid retention (swollen ankles), fatigue, nausea/vomiting

Also known as:

Dialysis, Renal dialysis, Hemodialysis, Continuous Ambulatory Peritoneal Dialysis - CAPD

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.