HIV/AIDS – Cannabis THC : CBD Ratios

HIV/AIDS Research Dashboard

30

Primary Studies

11

Related Studies

41

Total Studies

Clinical Studies

3

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

16

Meta-analyses/Reviews

5

Animal studies

6

Laboratory studies

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CannaKeys has 41 studies associated with HIV/AIDS.

Here is a small sampling of HIV/AIDS studies by title:


Components of the HIV/AIDS Research Dashboard

  • Dosing information available for HIV/AIDS
  • Chemotype guidance for treating HIV/AIDS with cannabis
  • Synopsis of cannabis research for HIV/AIDS
  • Individual study details for HIV/AIDS

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Overview - HIV/AIDS

Description of HIV/AIDS

Mainstream orthodox medicine considers acquired immune deficiency syndrome (AIDS) to be a disease of the immune system that is caused by a human immunodeficiency virus (HIV) transmitted through sexual or blood contact. Within a weakened immune system, infectious agents such as para- sites, fungi, bacteria, or viruses encounter little resistance from our natural defenses. Regardless of where in the body the infection spreads, the response is fever, sweat, chills, and any other defenses still available. The body's natural filters (including lymph nodes, liver, and kidneys) can become overwhelmed by the invaders, which further increases symptoms of weakness, low energy, and weight loss. This destructive process can develop into AIDS-related anorexia, cachexia, or wasting syndrome. Common opportunistic infections include lung infections by fungi (pneumocystis) or bacteria (pneumonia, tuberculo- sis), gastrointestinal infections such as candidiasis (thrush), infection of the nervous system and the brain by cryptococcal meningitis (fungus), progressive multifocal leukoencephalopathy (virus), or toxoplasmosis (parasite), which can lead to neuropathies (nerve pain) and dementia. Opportunistic diseases may also take the form of cancer (non-Hodgkin's lymphoma) or affect organs (hepatitis) or the skin (herpes). The orthodox medical establishment has no cure for AIDS. Current treatment consists of pharmaceutical antiviral agents belonging to two classes, namely protease inhibitors and reverse transcriptase inhibitors.

Disease Classification

Condition: HIV/AIDS
Disease Family: Infectious Disease (Viral)
Organ System: Immune System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B20

HIV/AIDS Symptoms:

Fever, swollen lymphs, unexpected weightloss, increased vulnerability to infection or other conditions (e.g. shingles, candidiasis, Kaposi's sarcoma), generalized weakness, pain in muscles or joints, sore throat (e.g. rash, thrush), night sweats, chronic diarrhea

Also known as:

HIV Infection, AIDS

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.