Gastroparesis – Cannabis THC : CBD Ratios

Gastroparesis Research Dashboard

4

Primary Studies

1

Related Studies

5

Total Studies

Clinical Studies

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

3

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 5 studies associated with Gastroparesis.

Here is a small sampling of Gastroparesis studies by title:


Components of the Gastroparesis Research Dashboard

  • Dosing information available for Gastroparesis
  • Chemotype guidance for treating Gastroparesis with cannabis
  • Synopsis of cannabis research for Gastroparesis
  • Individual study details for Gastroparesis

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Overview - Gastroparesis

Description of Gastroparesis

Some patients with this chronic condition are unable to move the content of their stomach and as such present with significant disturbances of process of digestion, absorption and elimination. Modern medicine considers gastroparesis an ideopathic condition i.e. of unknown origins. One theory focuses on potential damage to the vagus nerve responsible, in part, for peristalsis. Gastroparesis is not to be confused with other causes such as the adverse effects of numerous pharmacological drugs (e.g. opioids) that can display similar but typically temporary signs and symptoms.

Disease Classification

Condition: Gastroparesis
Disease Family:
Organ System: Digestive System
ICD-10 Chapter: Diseases of the digestive system
ICD-10 Code: K31.84

Gastroparesis Symptoms:

Abdominal distention, bloating, pain, nausea, vomiting (undigested food and drink), nutritional deficiencies, GERD, dehydration, blood sugar fluctuations, feeling of fullness after eating but little, loss of weight, decrease in quality of life. Hardening of undigested food causing blockages referred to as bezoar. Some patients only display mild symptoms or are asymptomatic. Potential risk or complicating conditions include: scleroderma, diabetes, Parkinson's disease, multiple sclerosis, Huntington's disease, previous abdominal trauma (e.g. surgery), previous chemotherapy (causing gastric neuropathy), hypothyroidism. Modern medicine offers no cure but manages signs and symptoms consisting primarily of dietary restriction, pharmaceutical medications (e.g. anti-emetics), or surgery (e.g. inserting a feeding tube into the small intestines or via endoscopic pyloromyotomy).

Also known as:

Delayed Gastric Emptying, Weak Peristalsis, Gastroparalysis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.