Eczema – Cannabis THC : CBD Ratios

Eczema Research Dashboard

3

Primary Studies

5

Related Studies

8

Total Studies

Clinical Studies

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 8 studies associated with Eczema.

Here is a small sampling of Eczema studies by title:


Components of the Eczema Research Dashboard

  • Dosing information available for Eczema
  • Chemotype guidance for treating Eczema with cannabis
  • Synopsis of cannabis research for Eczema
  • Individual study details for Eczema

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Overview - Eczema

Description of Eczema

The terms eczema and dermatitis are often used interchangeably to depicts a group of non-contagious, inflammatory, typically itchy skin conditions including the most common form of endogenous atopic dermatitis as well as exogenous forms such as irritant contact dermatitis or allergic contact dermatitis. Each type can share a number of symptom presentations such as inflammation, redness, heat, swelling, itching, which can also be painful. Symptom more unique to atopic dermatitis may also include dry, patchy scales, skin creases, rashes, small slightly raised bumps, and thickening of the skin. Within orthodox medicine precise causes are yet to be fully understood and vary depending on type: Atopic dermatitis is considered an chronic condition associated with a genetic vulnerability (mostly maternal) leading to weakened skin and an overreactive immune response; in contrast, irritant contact dermatitis occurs after direct contact with some form of chemical or irritant (e.g. poison ivy, bleach, pesticides, harsh cosmetics); while allergic contact dermatitis is due to the exposure to common allergens such as nickel, formaldehyde, or chromium for instance. The latter two forms tends to occur in acute forms and become self-correcting after the precise cause is discovered and eliminated. Additional environmental triggers that lead to break out in cases of atopic dermatitis may include: stress, anxiety, hormonal changes, diaphoresis, dry skin, low humidity, skin infections, or cold climates.

Disease Classification

Condition: Eczema
Disease Family: Skin Disease
Organ System: Integumentary System
ICD-10 Chapter: Diseases of the Skin and Subcutaneous Tissue
ICD-10 Code: L30.9

Eczema Symptoms:

Rash, itching, swelling, redness, pain, sometimes blister formation

Also known as:

Dermatitis, allergic contact dermatitis, irritant contact dermatitis, exogenous dermatitis, endogenous atopic dermatitis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.