Drug-Induced Bone Loss Research Dashboard
Double-blind human trials
Clinical human trials
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CannaKeys has 5 studies associated with Drug-Induced Bone Loss.
Here is a small sampling of Drug-Induced Bone Loss studies by title:
- Dronabinol inhibits alveolar bone remodeling in tooth movement of rats
- Cannabinoids and the skeleton: from marijuana to reversal of bone loss.
Components of the Drug-Induced Bone Loss Research Dashboard
- Dosing information available for Drug-Induced Bone Loss
- Chemotype guidance for treating Drug-Induced Bone Loss with cannabis
- Synopsis of cannabis research for Drug-Induced Bone Loss
- Individual study details for Drug-Induced Bone Loss
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Overview - Drug-Induced Bone Loss
Description of Drug-Induced Bone Loss
A number of pharmaceutical drugs cause bone loss, which in turn is responsible for a significant number of hip and vertebral fractures and as such of significant concern. Groups of pharmaceuticals that produce bone loss include glucocorticoids, hormonal drugs, selective inhibitors of serotonin reuptake, or heparins for example. Generally speaking the longer a person takes these drugs the greater the risk for bone loss. As such conscientious prescribing physicians attempt to limit the use of such substance to a minimum. However, in practice a great many people are on these drugs permanently making preventative measure ever more important. Recognized preventative measure include mineral supplements, vitamin D, weigh bearing exercise, and careful monitoring of vulnerable patient populations.
Drug-Induced Bone Loss
Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M83.5
Drug-Induced Bone Loss Symptoms:
Osteoradionecrosis, fractures, pain, asymetry, irregularity in joints
Also known as:
Drug-induced osteomalacia, Drug-induced bone softening
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.