Disorder of Synovium and Tendon – Cannabis THC : CBD Ratios

Disorder of Synovium and Tendon Research Dashboard

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CannaKeys has 1 studies associated with Disorder of Synovium and Tendon.

Here is a small sampling of Disorder of Synovium and Tendon studies by title:


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  • Chemotype guidance for treating Disorder of Synovium and Tendon with cannabis
  • Synopsis of cannabis research for Disorder of Synovium and Tendon
  • Individual study details for Disorder of Synovium and Tendon

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Overview - Disorder of Synovium and Tendon

Description of Disorder of Synovium and Tendon

A tendon is comprised of strong connective tissue that connects a muscle to a bone. For instance, the Achilles tendon starts at the base of the heel bone and connects it to the base of the calf muscle. It is named after the legendary Greek warrior Achilles of the Trojan war who was, as legend goes, invincible but for one vulnerability—his heel. The specific causes of tendinopathy are still subject to scientific investigation but contributing cause may include: micro tears, repetitive motion stress, certain pharmaceutical drugs (i.e. quinolone-based antibiotics), weight-related ischemia, or other conditions (e.g. arthritis, diabetes) for instance. And, while inflammation may play a role in some aspects of tendinopathy the microscopic lack of inflammatory cytokines puts tendinopathy outside the typical inflammatory disease classification.

Disease Classification

Condition: Tendon Disorders
Disease Family:
Organ System: Muscular System, Skeletal System
ICD-10 Chapter: Diseases of the musculoskeletal system and connective tissue
ICD-10 Code: M67

Disorder of Synovium and Tendon Symptoms:

The Achilles is the strongest tendon in the human body and if chronically affected, can produce significant pain in the surrounding tissues, swelling, as well as disability, a condition commonly referred to as tendinopathy. When tendinopathy progresses to show actual structural changes in the affected tissues (e.g. neovascularization, degeneration, tenocytes), usually in the center of the tendon, it is referred to as tendinopathy.

Also known as:

Synovial hypertrophy, Achilles Tendinosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.