Diarrhea – Cannabis THC : CBD Ratios

Diarrhea Research Dashboard

4

Primary Studies

0

Related Studies

4

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

2

Animal studies

1

Laboratory studies

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CannaKeys has 4 studies associated with Diarrhea.

Here is a small sampling of Diarrhea studies by title:


Components of the Diarrhea Research Dashboard

  • Dosing information available for Diarrhea
  • Chemotype guidance for treating Diarrhea with cannabis
  • Synopsis of cannabis research for Diarrhea
  • Individual study details for Diarrhea

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Overview - Diarrhea

Description of Diarrhea

Diarrhea is the rapid evacuation of bowel content. There are two basic forms of diarrhea, acute or chronic. Acute diarrhea is usually self-correcting (less than 14 days) once the initial cause such as the presence of unhealthy microbes (e.g. parasites, virus, bacteria, fungi) determined to be a threat to our health and well-being are eliminated. A number of pharmaceutical drugs (e.g. antibiotics, chemotherapy agents) or supplements (e.g. vitamin C) can cause diarrhea. Chronic forms of diarrhea (longer than 14 days) tend to have more complex pathological underpinnings such as those found in patients challenged by inflammatory bowel disease for example which may involve immune dysfunction, leaky gut, an out of balance or unhealthy microbiome, maintaining or contributing causes such as toxins or sustained form of stress, and other conditions such as hyperthyroidism or rectal/intestinal trauma for instance.

Disease Classification

Condition: Diarrhea
Disease Family: Gastrointestinal Disorder
Organ System: Digestive System
ICD-10 Chapter: Symptoms, Signs and Abnormal Clinical and Laboratory Findings
ICD-10 Code: R19.7

Diarrhea Symptoms:

Diarrhea is considered mild when it is slushy or mucinous in consistency while a completely liquid stool is considered severe. The longer especially severe diarrhea continues the higher the risk for developing additional symptoms which may include: abdominal pain or cramps, malabsorption of nutrients, dehydration, low blood pressure, risk of hypovolemic shock, pale skin, electrolyte imbalance, kidney dysfunction, weight loss, fever, blood in chyme, or a generalized weakness for example.

Also known as:

Dysentery, The Runs, The Trots, Montezuma's Revenge

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.