Diabetes Mellitus – Cannabis THC : CBD Ratios

Diabetes Mellitus Research Dashboard

35

Primary Studies

27

Related Studies

62

Total Studies

Clinical Studies

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

13

Meta-analyses/Reviews

17

Animal studies

4

Laboratory studies

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CannaKeys has 62 studies associated with Diabetes Mellitus.

Here is a small sampling of Diabetes Mellitus studies by title:


Components of the Diabetes Mellitus Research Dashboard

  • Dosing information available for Diabetes Mellitus
  • Chemotype guidance for treating Diabetes Mellitus with cannabis
  • Synopsis of cannabis research for Diabetes Mellitus
  • Individual study details for Diabetes Mellitus

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Overview - Diabetes Mellitus

Description of Diabetes Mellitus

Traditionally, orthodox medicine categorizes diabetes into three kinds: Type I, Type II, and gestational diabetes. Type I diabetes was once called juvenile diabetes because it occurred mostly in children or adolescents. In Type I, the pancreas stops producing the hormone insulin. Without insulin the body cannot use the food life depends on, cellular sugar. Treatment in the orthodox paradigm consists of daily insulin injections, normally administered by the patients themselves. Type II diabetes, or adult-onset diabetes, is the most common form of the disease. In Type II the pancreas does not produce enough insulin, or the body's cells are insensitive to the presence of insulin and ignore it. This prevents the body from converting sugar into energy. Early Type II usually does not require the use of insulin; modern medical practitioners generally prescribe oral pharmaceuticals instead. Diabetes, especially Type I or advanced Type II, is potentially life- threatening. Complications diminish one's life expectancy and quality of life. Gestational diabetes (diabetes that occurs during some pregnancies) most often self-corrects after delivery. While not very well understood, it is hypothesized that hormonal changes during pregnancy may produce a temporary resistance to insulin, thereby producing higher than normal blood sugar levels.

Disease Classification

Condition: Diabetes
Disease Family: Endocrine Disorder
Organ System: Endocrine System
ICD-10 Chapter: Endocrine, Nutritional and Metabolic Diseases
ICD-10 Code: E10-E13

Diabetes Mellitus Symptoms:

From mild to severe: Increased thirst (polydipsia), polyuria (increased frequency of urination), hypoglycemia, polyphasia (increased appetite), sweet smelling urine, (generalized weakness, blurred vision, itchy skin, slow healing wounds (especially at distal portion sof the limbs), diaphoresis, trembling, acetone-like smelling breath (ketoacidosis, Kussmaul breathing), agressive behavior, altered mental state, seizure activity, loss of consciousness, diabetic coma

Also known as:

Brittle diabetes, Gestational diabetes, neonatal diabetes, postprocedural diabetes, Type 2 diabetes,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.