Chronic Traumatic Encephalopathy – Cannabis THC : CBD Ratios

Chronic Traumatic Encephalopathy Research Dashboard

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CannaKeys has 1 studies associated with Chronic Traumatic Encephalopathy.

Here is a small sampling of Chronic Traumatic Encephalopathy studies by title:


Components of the Chronic Traumatic Encephalopathy Research Dashboard

  • Dosing information available for Chronic Traumatic Encephalopathy
  • Chemotype guidance for treating Chronic Traumatic Encephalopathy with cannabis
  • Synopsis of cannabis research for Chronic Traumatic Encephalopathy
  • Individual study details for Chronic Traumatic Encephalopathy

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Overview - Chronic Traumatic Encephalopathy

Description of Chronic Traumatic Encephalopathy

CTE is caused by repeated injuries to the brain which slowly and over time causes observable changes in body, mind, and emotion. It is considered a neurodegenerative illness and characterized by an overabundant accumulation of tau proteins in numerous regions of the brain. It is commonly observed in people who experienced repeated head injuries (e.g. boxing, rugby, American football). There is no cure within orthodox medicine and the few treatments that may be prescribed depend on specific symptoms.

Disease Classification

Condition: CTE
Disease Family: Trauma
Organ System: Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F07.81

Chronic Traumatic Encephalopathy Symptoms:

Cognitive impairment (e.g. memory loss, attention deficit, loss of planning ability), affectual/behavioral difficulties (e.g. hyperactivity, apathy, emotionally volatile, depression), dizziness

Also known as:

CTE, Postcontusional syndrome, Postconcussion syndrome

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.