Chagas Disease – Cannabis THC : CBD Ratios

Chagas Disease Research Dashboard

4

Primary Studies

2

Related Studies

6

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

3

Animal studies

1

Laboratory studies

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CannaKeys has 6 studies associated with Chagas Disease.

Here is a small sampling of Chagas Disease studies by title:


Components of the Chagas Disease Research Dashboard

  • Dosing information available for Chagas Disease
  • Chemotype guidance for treating Chagas Disease with cannabis
  • Synopsis of cannabis research for Chagas Disease
  • Individual study details for Chagas Disease

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Overview - Chagas Disease

Description of Chagas Disease

Chagas disease is a chronic condition caused by a parasite common in the South and Central Americas. The parasite (Trypanosoma cruzi) is primarily transmitted by a blood-feeding bug called 'kissing bug' or triatomine (kissing bug because they emerge at night and tend to feed on tissue around the eye and face). However, transmissions are also possible through contaminated food, contaminated blood transfusions, or it can be passed on from the mother to the fetus. Prevention measures include bite prevention methods, education about the of routes of transmission, improving housing and sanitation, insecticides or traps, mosquito nets, blood bank testing, and screening of at risk populations. Current pharmaceutical treatments have a very limited effectiveness in the first stage only. Their effectiveness further decreases as the parasite settles. Drugs include nifurtimox, benznidazole, and sometimes allopurinol. Each of these are toxic drugs with significant adverse effects. Treatment costs depend on country and severity of disease and can be significant.

Disease Classification

Condition: Chagas Disease
Disease Family: Infectious Disease (Parasite)
Organ System: Cardiovascular System, Digestive System, Nervous System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B57

Chagas Disease Symptoms:

Swelling at infection site (e.g. eye lids), fatigue, fever, rash, body ache, headache, nausea, vomiting, diarrhea, swollen lymph nodes, swollen liver or spleen, arrhythmias, heart failure

Also known as:

T Cuzi, Trypanosoma cruzi

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.