Celiac Disease – Cannabis THC : CBD Ratios

Celiac Disease Research Dashboard

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Primary Studies

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Related Studies

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Total Studies

Clinical Studies

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Double-blind human trials

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Clinical human trials

Pre-Clinical Studies

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Meta-analyses/Reviews

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Animal studies

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Laboratory studies

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CannaKeys has 2 studies associated with Celiac Disease.

Here is a small sampling of Celiac Disease studies by title:


Components of the Celiac Disease Research Dashboard

  • Dosing information available for Celiac Disease
  • Chemotype guidance for treating Celiac Disease with cannabis
  • Synopsis of cannabis research for Celiac Disease
  • Individual study details for Celiac Disease

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Overview - Celiac Disease

Description of Celiac Disease

Celiac disease is a chronic auto-immune condition that affects the small intestines. The condition is associated with an imbalance in the microbiome. The cause is hypothesized to be an intolerance to gluten and indeed many patients report relief from using a gluten free diet. However, alternatively other causative considerations include the involvement of glyphosate, the active ingredient in Roundup which is thought to interfere with enzymatic pathways (P450) needed to break down environmental toxins.

Disease Classification

Condition: Celiac Disease
Disease Family: Autoimmune Disorder
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K90.0

Celiac Disease Symptoms:

Abdominal discomfort (e.g. diarrhea, constipation, bloating, flatulence, heartburn), symptom worsen with intake of gluten rich foods, weight loss, anemia (from iron deficiency), depression, generalized weakness, headache, joint pain, loss of bone density (including teeth), skin rash (similar to herpetic blister formation)

Also known as:

Celiac gluten-sensitive enteropathy, celiac sprue, sprue

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.