Benzodiazepine Use Disorder – Cannabis THC : CBD Ratios

Benzodiazepine Use Disorder Research Dashboard

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Primary Studies

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Related Studies

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Total Studies

Clinical Studies

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Double-blind human trials

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Clinical human trials

Pre-Clinical Studies

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Meta-analyses/Reviews

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Animal studies

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Laboratory studies

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CannaKeys has 3 studies associated with Benzodiazepine Use Disorder.

Here is a small sampling of Benzodiazepine Use Disorder studies by title:


Components of the Benzodiazepine Use Disorder Research Dashboard

  • Dosing information available for Benzodiazepine Use Disorder
  • Chemotype guidance for treating Benzodiazepine Use Disorder with cannabis
  • Synopsis of cannabis research for Benzodiazepine Use Disorder
  • Individual study details for Benzodiazepine Use Disorder

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Overview - Benzodiazepine Use Disorder

Description of Benzodiazepine Use Disorder

Benzodiazepines are a class of psychoactive pharmaceuticals that are commonly prescribed to treat anxiety, insomnia, alcohol withdrawal symptoms (e.g. delirium tremors), or panic attacks for example. Benzos as they are sometimes called in colloquial vernacular have sedative, sleep-inducing (hypnotic), relaxant, mood improving properties that can express themselves therapeutically (see sample indications) or as adverse effects such as confusion, memory loss, dizziness, low blood pressure, reduced respiratory rates, addiction, increase in risky or pathological behavior, overdose, and death. Speed of onset of effects, the time it take to break it down (metabolize), and potency of benzodiazepine type are in direct relationship to risk of developing benzodiazepine use disorder. Reviews of available trials, epidemiological studies, clinical expert opinions, interviews with people suffering from benzodiazepine use disorder, and alike suggest that diazepam, lorazepam and alprazolam tend to present a relatively higher risk of abuse potential, while oxazepam for instance presented with a lower one.

Disease Classification

Condition: Benzo Use Disorder
Disease Family:
Organ System: Mental/Emotional System
ICD-10 Chapter: Mental, Behavioral and Neurodevelopmental disorders
ICD-10 Code: F13

Benzodiazepine Use Disorder Symptoms:

Severe physical and mental-emotional withdrawal symptoms such as ataxia (unsteady gait), confusion, dysphoria, muscle twitching, dizziness, hallucinations.

Also known as:

Addiction to Benzodiazepines, Benzodiazepines Abuse, Valium Use Disorder, Sedative, hypnotic, or anxiolytic related disorders

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.