Atherosclerosis – Cannabis THC : CBD Ratios

Atherosclerosis Research Dashboard

8

Primary Studies

9

Related Studies

17

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

4

Animal studies

3

Laboratory studies

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CannaKeys has 17 studies associated with Atherosclerosis.

Here is a small sampling of Atherosclerosis studies by title:


Components of the Atherosclerosis Research Dashboard

  • Dosing information available for Atherosclerosis
  • Chemotype guidance for treating Atherosclerosis with cannabis
  • Synopsis of cannabis research for Atherosclerosis
  • Individual study details for Atherosclerosis

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Overview - Atherosclerosis

Description of Atherosclerosis

In the past, atherosclerosis was largely defined in terms of the accumulation of plaque or bad cholesterol (LDL) within the arterial walls, leading to obstructions. However, it is now understood to be more than a simple build-up of plaque. This obstruction is actually a physical response to injuries in the walls' lining. Causes of arterial wall injuries include high blood pressure, infectious microbes, or excessive presence of a certain amino acid called homocysteine. Studies have demonstrated that inflammatory molecules stimulate events leading to the development of atherosclerotic lesions. Some researchers consider atherosclerosis a natural type of band-aid approach to cover an injury or inflammation. When the band-aid becomes too thick or breaks loose, symptoms of a chronic or acute nature occur. In mild cases, this can lead to diminished oxygen supply to the tissue on the other side of the occlusion; in acute cases, it can cause severe strokes or heart attacks.

Disease Classification

Condition: Atherosclerosis
Disease Family: Inflammatory Disease
Organ System: Cardiovascular System
ICD-10 Chapter: Diseases of the Circulatory System
ICD-10 Code: I70

Atherosclerosis Symptoms:

The narrowing of the arteries to the heart may cause symptoms such as shortness of breath, dizzyness, altered mental state, chest pain, pain radiating down the left arm, pale skin, diaphoresis, nausea and vomiting, angina, arrthmias, myocardial infaction. The narrowing of the arteries to the brain can cause symptoms such as severe headache, cognitive dysfunction, dizzyness, loss of consciousness, blurred vision, numbness to face, stroke, jugular vein distention for example.

Also known as:

Atherosclerosis, Monckeberg (medial) sclerosis, Atherosclerotic gangrene, Goldblatt Kidney, Artery Occlusion

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.