Arthritis – Cannabis THC : CBD Ratios

Arthritis Research Dashboard

13

Primary Studies

5

Related Studies

18

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

5

Animal studies

2

Laboratory studies

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CannaKeys has 18 studies associated with Arthritis.

Here is a small sampling of Arthritis studies by title:


Components of the Arthritis Research Dashboard

  • Dosing information available for Arthritis
  • Chemotype guidance for treating Arthritis with cannabis
  • Synopsis of cannabis research for Arthritis
  • Individual study details for Arthritis

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Overview - Arthritis

Description of Arthritis

Arthritis is inflammation of a joint connecting two bones such as the fingers, wrists, hips, back, and knee joints. People suffering from arthritis often complain of pain in the affected joint, which is commonly accompanied by redness, a sensation of heat, and minor swelling. Arthritis typically develops gradually over many years. Initially, it presents as an occasional mild ache in the joints which progresses into chronic pains, stiffness, and swelling. The arthritis sufferer begins to avoid certain painful movements so as to guard against the pain, resulting in further stiffness, limited range of motion, and decreased mobility. Arthritis has become the leading cause of disability in the U.S., with more than 46 million people suffering various forms of physical difficulties. Western medicine claims little specific knowledge of the causes or cures of this ailment. However, more than one hundred different causes for arthritis are considered, including gout and scleroderma, and viral, bacterial, or fungal infections. Limited treatments focus on suppressing pain and/or diminishing inflammation flare-ups.

Disease Classification

Condition: Arthritis
Disease Family: Inflammatory Disease
Organ System: Skeletal System
ICD-10 Chapter: Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M13

Arthritis Symptoms:

Pain, reduced range of motion, stiffness, swelling of joints, redness

Also known as:

Osteoarthritis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.