Amyloidosis and Familial Mediterranean Fever – Cannabis THC : CBD Ratios

Amyloidosis and Familial Mediterranean Fever Research Dashboard

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Primary Studies

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Related Studies

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Total Studies

Clinical Studies

1

Double-blind human trials

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Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

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CannaKeys has 2 studies associated with Amyloidosis and Familial Mediterranean Fever.

Here is a small sampling of Amyloidosis and Familial Mediterranean Fever studies by title:


Components of the Amyloidosis and Familial Mediterranean Fever Research Dashboard

  • Dosing information available for Amyloidosis and Familial Mediterranean Fever
  • Chemotype guidance for treating Amyloidosis and Familial Mediterranean Fever with cannabis
  • Synopsis of cannabis research for Amyloidosis and Familial Mediterranean Fever
  • Individual study details for Amyloidosis and Familial Mediterranean Fever

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Overview - Amyloidosis and Familial Mediterranean Fever

Description of Amyloidosis and Familial Mediterranean Fever

Amyloidosis is an umbrella term that describes a number of similar conditions in which abnormal proteins build up in parts of the human body. In Familial Mediterranean Fever a mutation in the gene that produces the amino-acid pyrin causes episodic and overly reactive inflammatory response most commonly in the abdomen, chest and the joints. The condition is characterized by irregular but recurring flare-ups. The associating pain and fevers are commonly treated with analgesia and NSAIDs. In between flare-ups patients are usually asymptomatic.

Disease Classification

Condition: Fam. Mediterranean Fever
Disease Family: Inflammatory Disease (Hereditary)
Organ System: Digestive System
ICD-10 Chapter: Endocrine, Nutritional and Metabolic Diseases
ICD-10 Code: E85

Amyloidosis and Familial Mediterranean Fever Symptoms:

Fever, abdominal pain (can be severe), inflammation, painful swollen joints, rash around the ankles, pleural pain, occasional testicular swelling, high white blood cell count

Also known as:

FMF, Amyloidosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.