Terpinolene – Terpenes and Cannabinoid Research

Terpinolene Research Dashboard


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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 26 studies associated with Terpinolene.

Here is a small sampling of Terpinolene studies by title:

Components of the Terpinolene Research Dashboard

  • Top medical conditions associated with Terpinolene
  • Proven effects in clinical trials for Terpinolene
  • Receptors associated with Terpinolene
  • Individual study details for Terpinolene

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Overview - Terpinolene

What is Terpinolene?

Terpinolene is a terpene with a complex aroma profile similar to lilac.

It is present in relatively low concentrations of cannabis and other sources.

Terpinolene may have properties that are sedating, anxiolytic, anti-cancer, anti-bacterial, and anti-oxidant, and may help prevent heart disease.

Is Terpinolene safe?

Terpinolene is a clear and colorless liquid with a flowery aroma that the FDA has approved as a food additive for human consumption (FDA PART 172).

However, in isolated and concentration-dependent forms, terpinolene is flammable in liquid and vapor form and can cause skin and eye irritation and allergic skin reactions. In addition, it can be fatal if an isolated or highly concentrated form is swallowed or inhaled due to hemorrhagic damage to gastric mucosa or aspiration.

Other Names

IUPAC Name: 1-methyl-4-propan-2-ylidenecyclohexene


Scent Description

Herbal, pine, citrus, floral, lilac

Natural Sources

Tea-tree, lilac, citrus fruits, navel oranges, apples

Cannabis Strains High in Terpinolene

Ultra Sour, Dutch Treat, Sensi Star, Ace of Spades, Sour Tsunami, Afghani Kush, Purple Kush, CBD Skunk Haze, Lemon Skunk, Blue Cheese, Banana Blaze, Lemon Kix, Chocolope

Terpinolene Properties and Effects

Terpinolene is associated with the following properties and effects:

  1. Anti-cancer (antiproliferative against brain cancer cells) (E. Aydin et al., 2013)

  2. Wound healing agent (M. de Christo Scherer et al., 2019)

Anxiolytic and sedative (via potential anti-acetylcholinesterase and anti-butyrylcholinesterase activity, potent central nervous system depressant activity yet to be further explored)

Anti-cancer effects in mice and cancer models of neuroblastoma, breast, cervical, leukemic, and melanoma cells (via dose-dependent antiproliferative effects mainly attributed to antioxidant effects, reduced protein expression of AKT1 in K562 human leukemic cells, pro-apoptosis, and other antitumor mechanisms yet to be defined)

Anti-bacterial effects on Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Propionibacterium, and Escherichia coli.

Antifungal effects on Candida Albicans, Aspergillus Niger, Saccharomyces cerevisiae, as well as the spores of Diplodia pinea (via growth inhibition with relatively low MIC, specific mechanisms yet to be determined)

Antioxidant and anti-inflammatory features, possible analgesia synergistic with NSAIDS (via potential involvement of 5HT1A receptors, reduction of IL-1β and TNF-α cytokines)

May help prevent heart disease (via inhibiting oxidative modification of low-density lipoproteins, specifically against copper-induced oxidation and prevention of the oxidation of LDL protein)

Last reviewed by Dr. Abraham Benavides, M.D., 06-29-2022

Terpinolene Receptor Binding

Endocannabinoid System (ECS) and Terpinolene:

  1. CB1 (agonist) (N. Raz et al., 2023)

Endocannabinoidome (eCBome) and Terpinolene:


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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.