Terpinolene – Terpenes and Cannabinoid Research

Terpinolene Research Dashboard

15

Primary Studies

9

Related Studies

24

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

3

Animal studies

10

Laboratory studies

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CannaKeys has 24 studies associated with Terpinolene.

Here is a small sampling of Terpinolene studies by title:


Components of the Terpinolene Research Dashboard

  • Top medical conditions associated with Terpinolene
  • Proven effects in clinical trials for Terpinolene
  • Receptors associated with Terpinolene
  • Individual study details for Terpinolene

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Overview - Terpinolene

Terpinolene

Terpinolene is a terpene with a complex aroma profile similar to lilac. It is present in relatively low concentrations in cannabis and other sources. Terpinolene may have properties that are sedating, anxiolytic, anti-cancer, anti-bacterial, anti-oxidant, and may help prevent heart disease

Description of Terpinolene and Cautions

Terpinolene is a clear and colorless liquid with a flowery aroma that has been approved by the FDA as a food additive for human consumption (FDA PART 172). However in isolated forms, terpinolene is flammable in liquid and vapor form and can cause skin and eye irritation, and allergic skin reactions. It can be fatal if the isolated form is swallowed or inhaled due to hemorrhagic damage to gastric mucosa or aspiration.
–Source: PubChem

Scent Description

Herbal, pine, citrus, floral, lilac

Natural Sources

Tea-tree, lilac, citrus fruits, navel oranges, apples

Summary of Terpinolene Effects

Anxiolytic and sedative (via potential anti-acetylcholinesterase and anti-butyrylcholinesterase activity, potent central nervous system depressant activity yet to be further explored)

Anti-cancer effects in mice and cancer models of neuroblastoma, breast, cervical, leukemic, and melanoma cells (via dose-dependent antiproliferative effects mainly attributed to antioxidant effects, reduced protein expression of AKT1 in K562 human leukemic cells, pro-apoptosis, and and other antitumor mechanisms yet to be defined)

Anti-bacterial effects on Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Propionibacterium, and Escherichia coli. Antifungal effects on Candida Albicans, Aspergillus Niger, Saccharomyces cerevisiae, as well as the spores of Diplodia pinea (via growth inhibition with relatively low MIC, specific mechanisms yet to be determined)

Antioxidant and anti-inflammatory features, possible analgesia synergistic with NSAIDS (via potential involvement of 5HT1A receptors, reduction of IL-1β and TNF-α cytokines)

May help prevent heart disease (via inhibiting oxidative modification of low-density lipoproteins, specifically against copper-induced oxidation and prevention of the oxidation of LDL protein)

Last reviewed by Dr. Abraham Benavides M.D., 06-29-2022

Cannabis Strains High in Terpinolene

Ultra Sour, Dutch Treat, Sensi Star, Ace of Spades, Sour Tsunami, Afghani Kush, Purple Kush, CBD Skunk Haze, Lemon Skunk, Blue Cheese, Banana Blaze, Lemon Kix, Chocolope

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.