Curcumin Activates CB2 Receptor Sites

This is potentially great news for people with diabetes with a 2- to 4-fold higher risk of developing cardiovascular disease. Resulting data revealed that the oral consumption of curcumin-induced activation of endocannabinoid receptor 2 (CB2) resulted in a cardioprotective effect in diabetic mice fed a high-fat diet. More specifically, using oral curcumin at 200 mg/kg/day protected the test animals from heart attacks resulting in compensation for hemodynamic fluctuations, restoring biochemical markers, preserving antioxidant capacity, decreasing cytokines levels, and restoring cardiac functionality. As such, turmeric has become one of the latest readily available additions to the endocannabinoidome (eCBome), which may be harnessed to mitigate the shared pathophysiology of many inflammatory conditions and support the physiology of well-being.