Study Spotlight #1: Curcumin at CB2 results in cardioprotective effects
This is potentially great news for people with diabetes with a 2- to 4-fold higher risk of developing cardiovascular disease. Resulting data revealed that the oral consumption of curcumin-induced activation of endocannabinoid receptor 2 (CB2) resulted in a cardioprotective effect in diabetic mice fed a high-fat diet. More specifically, using oral curcumin at 200 mg/kg/day protected the test animals from heart attacks resulting in compensation for hemodynamic fluctuations, restoring biochemical markers, preserving antioxidant capacity, decreasing cytokines levels, and restoring cardiac functionality. As such, turmeric has become one of the latest readily available additions to the endocannabinoidome (eCBome), which may be harnessed to mitigate the shared pathophysiology of many inflammatory conditions and support the physiology of well-being.
Pawar HD, Mahajan UB, Nakhate KT, Agrawal YO, Patil CR, Meeran MFN, Sharma C, Ojha S, Goyal SN. Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors. Life (Basel). 2022 Apr 22;12(5):624.