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Sabinene – Terpenes and Cannabinoid Research

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Overview - Sabinene

What is Sabinene?

Sabinene is a naturally occurring bicyclic monoterpene isolated from the essential oils of various plant species. Sabinene is a chiral molecule that exists as (+) and (-) enantiomers, i.e., one of two stereoisomers not superposable onto their mirror image, similar to the left and right hand.


Is Sabinene safe?


In their highly concentrated form, both enantiomers of sabinene are a liquid and vapor that are highly flammable and harmful if swallowed. Exposure to either enantiomer in their concentrated forms can irritate the mucous membranes and the skin.

Other Names

IUPAC Name [(+)-Sabinene]: (1R,5R)-4-methylidene-1-propan-2-ylbicyclo[3.1.0]hexane


IUPAC name [(-)-Sabinene]: (1S,5S)-4-methylidene-1-propan-2-ylbicyclo[3.1.0]hexane


Source–PubChem

Scent Description

Warm and spicy.

Natural Sources

The essential oil of wild carrot seeds contains a significant amount of sabinene, up to 40% twice that of cultivated carrot seeds (M. Aćimović et al., 2016).

Cannabis Cultivars High in Sabinene

Durban Poison, Grapefruit

Sabinene Properties and Effects

Sabinene is associated with the following properties and effects:



  1. Analgesic

  2. Anticancer

  3. Antidiabetic

  4. Anti-inflammatory

  5. Anti-microbial

    1. Streptococcus Mutans (may prevent cavities) (Bog-Im Park et al., 2023)



  6. Antioxidant

Sabinene Receptor Binding

Endocannabinoid System (ECS) and Sabinene:



  1. CB1 (agonist) (N. Raz et al., 2023)


Endocannabinoidome (eCBome) and Sabinene:



  1. MAPK–MuRF-1 Pathway (Mitogen-activated protein kinase–muscle ring-finger protein-1) (Sabinene inhibits) (may reduce muscle atrophy) (Yunkyoung Ryu et al., 2019)

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