Pharma THC Cannabinoid Research

Pharma THC Research Dashboard

220

Primary Studies

90

Related Studies

310

Total Studies

Clinical Studies

30

Clinical Meta-analyses

72

Double-blind human trials

30

Clinical human trials

Pre-Clinical Studies

72

Meta-analyses/Reviews

11

Animal studies

5

Laboratory studies

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CannaKeys has 310 studies associated with Pharma THC.

Here is a small sampling of Pharma THC studies by title:


Components of the Pharma THC Research Dashboard

  • Top medical conditions associated with Pharma THC
  • Proven effects in clinical trials for Pharma THC
  • Receptors associated with Pharma THC
  • Individual study details for Pharma THC

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Overview - Pharma THC

Description of Pharma THC

Pharmaceutical drugs [i.e., Dronabinol (Marinol®, Syndros®) and also Nabilone (Cesamet®)] containing THC correspond to a cannabis chemotype I. They represent a class of drugs produced and standardized from synthetic sources.


Here we highlight dronabinol:


  • Dronabinol is a synthetic version of THC.

  • FDA approved in 1985 for the tx of HIV/AIDS-induced anorexia & chemotherapy-induced nausea.

  • Off-label use includes chronic pain, obstructive sleep apnea, substance abuse, and withdrawal.

  • The standard dose for research is 5mg THC. The National Institute for Drug Abuse (NIDA) declared to measure and report clinical research findings using a standard unit of delta-9-tetrahydrocannabinol (THC) of 5 mg (NIDA, 2021).

  • Dronabinol is available as soft gelatin capsules: 2.5 mg (white), 5 mg (dark brown), and 10mg (orange).

  • Contraindications to dronabinol include a history of hypersensitivity reaction to sesame oil or THC derivatives.

  • The most common adverse effects may include changes in cognition, dizziness, euphoria, nausea, anxiety, vomiting, or abdominal discomfort.

  • Dronabinol has a half-life of ~4 hours.

  • An estimated lethal human dose of dronabinol (IV) is 30 mg/kg (i.e., 2100 mg/ 70 kg).

  • Dronabinol has an onset time of ~ 1/2  to 1 hour with a peak effect at 2 to 4 hours.

  • Dronabinol has not been evaluated for geriatric or pediatric use.


While Dronabinol (Marinol®, Syndros®) and Nabilone (Cesamet®) are synthetic forms of delta-9-THC, both have different molecular formulas (see names text box), resulting in diverse adverse effects potential for more information on the differences of potential adverse effects between Dronabinol (Marinol®, Syndros®) and Nabilone (Cesamet®) see below.


In this systematic review and meta-analyses of clinical trials (2022), Dronabinol presented 111 "diverse but not severe" adverse effects, while Nabilone presented 40. 



  • Occurrences of dizziness and dry mouth were most commonly noted in both Dronabinol and Nabilone treatment groups. Similarly, nausea, drowsiness, and fatigue occurred with similar frequency. 

  • However, adverse effects of dizziness, dry mouth, and headache were significantly higher in patients treated with Dronabinol.

  • Drowsiness was >7 x as frequent in patients treated with nabilone than in the placebo group. 

Other Names:

Pharmaceutical THC

Dronabinol (Marinol®, Syndros®) is a synthetic delta-9-tetrahydrocannabinol, Delta-9-THC (plus various other supplier-based synonyms).


IUPAC Name: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol


Molecular Formula: C21H30O2


Source–PubChem


Nabilone (Cesamet®) is a synthetic delta-9-Tetrahydrocannabinol derivative. (plus various other supplier-based synonyms).


IUPAC Name: (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one


Molecular Formula: C24H36O3


Source–PubChem

Pharma THC Properties and Effects

Only Members can view Properties and Effects information. See DEMO page.

Pharma THC Receptor Binding

Only Members can view Receptor Binding information. See DEMO page.

Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.