Omega-6 Cannabinoid Research

Omega-6 Research Dashboard

3

Primary Studies

0

Related Studies

3

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

0

Animal studies

2

Laboratory studies

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CannaKeys has 3 studies associated with Omega-6.

Here is a small sampling of Omega-6 studies by title:


Components of the Omega-6 Research Dashboard

  • Top medical conditions associated with Omega-6
  • Proven effects in clinical trials for Omega-6
  • Receptors associated with Omega-6
  • Individual study details for Omega-6

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Overview - Omega-6

Description of Omega-6

Polyunsaturated fatty acids (PUFAs) are essential building blocks. Since the human body does not make its own PUFAs, we must consume them to survive and thrive. PUFAs such as omega-6 (and omega-3) fatty acids are primary building blocks the body uses to make its own endocannabinoids. And, omega-6-based endocannabinoids are considered multi-functional molecules acting at various receptor sites.


Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are made from arachidonic acid (ARA), the more abundant omega-6 (n6) in the brain. Levels of ARA determine the levels of 2-AG and AEA. Western diet a high ratio of n6:n3 may lead to an overstimulation of the ECS resulting in increased neuroinflammation, neurodegeneration, and pathological aging (S. Dyall 2017).


However, here is an important insight: a healthy ECS is dependent on the ratio of omega-3 to omega-6.

Other Names:

Arachidonic acid (ARA)

IUPAC name: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid (plus numerous other supplier-based synonyms)


Source–PubChem

Omega-6 Properties and Effects

The Endocannabinoid System (ECS) and Omega-6:


  •  Western diet a high ratio of n6:n3 may lead to an overstimulation of the ECS resulting in increased neuroinflammation, neurodegeneration, and pathological aging (S. Dyall 2017)

  • ARA increased AEA levels and inhibited glioblastoma in vitro (R. Gastón et al., 2017)

  • The ideal dietary ratio is about 5:1 (n-6:n-3) (C. Bosch-Bouju et al., 2015)

  • A modern (esp. western) diet is unbalanced with a ratio of ~20:1 (n-6:n-3) (C. Bosch-Bouju et al., 2015)


 

Omega-6 Receptor Binding

N/A

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.