Omega-3 Cannabinoid Research

Omega-3 Research Dashboard


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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 27 studies associated with Omega-3.

Here is a small sampling of Omega-3 studies by title:

Components of the Omega-3 Research Dashboard

  • Top medical conditions associated with Omega-3
  • Proven effects in clinical trials for Omega-3
  • Receptors associated with Omega-3
  • Individual study details for Omega-3

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Overview - Omega-3

Description of Omega-3

Polyunsaturated fatty acids (PUFAs) are essential building blocks. Since the human body does not make its own PUFAs, we must consume them to survive and thrive. In the brain PUFAs omega-3 (DHA and EPA) fatty acids are primary building blocks (or precursors) the body uses to make its own endocannabinoids (as are omega-6). Omega-3-based endocannabinoids are multi-functional molecules acting at various receptor sites. 

And here is an important insight: a healthy ECS is dependent on the ratio of omega-3 to omega-6.

Excess of omega-6 and a lack of dietary omega-3 are implicated in a poorly functioning ECS.

The findings have practical implications in the setting of chronic illness (especially those with chronic pain, inflammation, and oxidative stress). We can choose to consume foods that prevent or treat ECS-based dysfunction or impairment.

More specifically, omega-3’s are considered anti-inflammatory while omega-6 is a precursor to a number of potent pro-inflammatory mediators.

When we consider that our modern diet is heavy in omega-6 and low in omega-3 at an estimated ratio of 20:1 (respectively), we can more easily make a connection between the foods we eat and a low bioavailability of endocannabinoids, with direct consequences for a number of chronic conditions.

Research suggests that a healthy ratio is 5:1 (omega-6:omega-3).

Foods and oils rich in omega-3 include fish such as salmon, mack- erel, and sardines; also cod liver oil, hemp seed oil, flax seed oil, and chia seed oil are good sources (as are the seeds them- selves).

In direct contrast, omega-6-abundant food sources include numerous oils (e.g. corn oil, soybean oil, cottonseed oil), but especially corn chips or most fast foods (due to being fried or in processed oils abundant in omega-6).

Other Names:

Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA)

IUPAC name for docosahexaenoic acid (DHA): (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid

IUPAC name eicosapentaenoic acid (EPA): (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid

Both DHA and EPA have numerous other supplier-based synonyms.


Omega-3 Properties and Effects

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Omega-3 Receptor Binding

Only Members can view Receptor Binding information. See DEMO page.

Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.