Nerolidol – Terpenes and Cannabinoid Research

Nerolidol Research Dashboard


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CannaKeys has 36 studies associated with Nerolidol.

Here is a small sampling of Nerolidol studies by title:

Components of the Nerolidol Research Dashboard

  • Top medical conditions associated with Nerolidol
  • Proven effects in clinical trials for Nerolidol
  • Receptors associated with Nerolidol
  • Individual study details for Nerolidol

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Overview - Nerolidol

What is Nerolidol?

Nerolidol has a fresh and woody scent.

Poor skin penetration limits the bioavailability of drugs used to treat certain conditions, especially those of the skin.

Similar to DMSO, nerolidol can enhance skin penetration and, as such, may help focus the delivery of drugs where they are needed.

Nerolidol may produce effects that are soothing, antispasmodic, antifungal, anti-parasite, antioxidant, anti-inflammatory, anxiolytic, synergistic with pharmaceutical antibiotics, enhancing drug absorption, and anti-cancer activities in vitro.

Is Nerolidol safe?

Nerolidol appears as an oily liquid ranging in color from colorless to yellow. The FDA has approved it as a food additive for human consumption (FDA PART 172). Depending on concentration, it can cause eye, skin, and respiratory irritation.

Other Names

IUPAC Name: (6E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol


Scent Description

Woody, floral, citrus

Natural Sources

Tea tree oil, ginger, lemongrass, citrus peel

Cannabis Strains High in Nerolidol

Sour Diesel, OG Kush, Cannatonic Blackberry, Ghost Train Haze, Lemon Kush, Afghan Kush, Lemon Skunk, CBD Skunk Haze, Blue Cheese, Chocolope

Nerolidol Properties and Effects

Nerolidol is associated with the following properties and effects:

  1. Anti-cancer

    1. Apoptotic (to osteosarcoma cells) (Y. Yu et al., 2022)

  2. Cardio-protective (attenuated acute MI in test animals) (M. Gonçalves et al., 2022)

Sedative, analgesic, anxiolytic in mice (via possible opioid-insensitive, GABAergic mechanisms without the involvement of KATP channels, weak TRPV1 activation, anti-inflammatory activities)

Antispasmodic and gastroprotective activity (via inhibition of gastric ulcer formation in mice, possible inhibition of voltage-dependent calcium channels, modulation of potassium channels, and modulation of intracellular cAMP)

Antioxidant, anti-arthritic in rat models of rheumatoid arthritis, may protect from damage caused by thioacetamide in mouse heart and kidney tissue, attenuates MI caused by ISO by a marked reduction in myocardial infarct size and suppression of oxidative stress in mice (via a decrease in overexpression of TNF-α, IL-1β, IL-6, NF-kB, PGE-2 and COX-2 while increasing IL-10, IL-4, and serum antioxidant activity)

Antifungal (via inhibiting growth of fungi like Microsporum gypseum while reducing hyperkeratosis and inflammatory cell infiltration)

Anti-parasite (via activity against babesiosis, leishmaniasis, and anti-protozoal parasite control benefits for malaria)

Antibacterial and may be synergistic with pharmaceutical antibiotics (via toxicity against Salmonella enterica, Staphylococcus aureus, Escherichia coli, and Aspergillus niger, and increasing the antibacterial activity of antibiotics)

May enhance drug absorption and produce pharmaceutical synergies (via enhancing absorption of doxorubicin in resistant cancer cell lines, diclofenac, 5-fluorouracil, and in nanocarrier systems)

Anti-inflammatory suppresses the inflammatory response during LPS-induced Acute Lung Injury, anti-NASH and anti-fibrotic properties in mice (via modulation of antioxidant enzymes, reduced levels of TNF-α and IL-1β in LPS-stimulated peritoneal macrophages, the possible involvement of TLR4, Nrf2, and NF-κB pathways, the AMPK/Nrf-2/HO-1 pathway, reducing steatosis (macrovesicular and microvesicular), degeneration of hepatocytes, inflammatory cell infiltration, circulatory TNF-α, and tissue collagen, significantly reduced hepatic lipid accumulation and halted NASH disease progression induced by a hypercaloric diet)

Neuroprotective and anticonvulsant in mouse models of epilepsy and ROT-induced Parkinson’s Disease also improved depression and memory loss in the PTZ-kindled animals (via increased NE, DA, 5-HT in cortex and hippocampus, reduced oxidative stress, increasing levels of SOD, CAT, and GSH, and decreased the level of MDA, inhibiting the release of proinflammatory cytokines and inflammatory mediators, preventing ROT-induced glial cell activation and the loss of dopaminergic neurons and nerve fibers, and ultimately attenuated ROT-induced dopaminergic neurodegeneration)

It may have anti-cancer activity (via significantly enhanced apoptosis in Caco-2 (human colon cancer) in vitro cells, inducing apoptosis via PI3K/JNK regulation through cell cycle arrest in MG-63 osteosarcoma cells, synergy with doxorubicin in resistant cancer cell lines, diminishing experimentally induced formation of colon adenomas in mice, modulating biochemical profiles (antioxidants, detoxification, LPO, and renal function markers), and inhibiting tumor development in DMBA-induced oral carcinogenesis in mice)

Last reviewed by Dr. Abraham Benavides, M.D., 05-21-2022

Nerolidol Receptor Binding

Endocannabinoid System (ECS) and Nerolidol:


Endocannabinoidome (eCBome) and Nerolidol:


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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.