Myrcene – Terpenes and Cannabinoid Research

Myrcene Research Dashboard

32

Primary Studies

19

Related Studies

51

Total Studies

Clinical Studies

0

Clinical Meta-analyses

2

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

12

Animal studies

13

Laboratory studies

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CannaKeys has 51 studies associated with Myrcene.

Here is a small sampling of Myrcene studies by title:


Components of the Myrcene Research Dashboard

  • Top medical conditions associated with Myrcene
  • Proven effects in clinical trials for Myrcene
  • Receptors associated with Myrcene
  • Individual study details for Myrcene

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Overview - Myrcene

Myrcene

Myrcene is a monoterpene that in very diluted forms tastes like mango.

Myrcene makes THC more biologically available by increasing the saturation level and speed at CB1 and thus boosting THC’s properties.

Higher concentrations of β-myrcene in cannabis tend to produce the feelings of heavy, deep relaxation. Additionally, potential properties of myrcene include sleep-inducing, analgesia, anti-inflammatory, antioxidant, anxiolytic, anti-Alzheimer’s, protective against peptic ulcers, and may be protective against breast cancer.

Description of Myrcene and Cautions

The isolated terpene is a colorless clear liquid which is flammable. In solutions where myrcene percentage values are above 10%, it may cause skin, eye, and respiratory irritation, including serious and possibly fatal complications if swallowed.
–PubChem

Scent Description

Berries, herbal, woody, floral, root-vegetable

Natural Sources

Hops, mango, bay leaves, lemongrass

Summary of Myrcene Effects

Anxiolytic, anticonvulsive, sedating, possible sleeping aid, potentiates barbiturate-induced sleep in mice (via glutamatergic and GABAergic receptor activity)

Anti-inflammatory (via prostaglandin E2, reducing cytokine production, and inhibiting NF-κB and MAPK in LPS-stimulated murine macrophages)

Antioxidant and anti-aging. May play a protective role against UVB-induced human skin photo-aging and oxidation (via increased glutathione along with other antioxidant enzymes such as glutathione peroxidase (GPx) and superoxide dismutase, decreased production of ROS, MMP-1, MMP-3, interleukin-6 (IL-6) and increased transforming growth factor type 1 (TGF-1) and type I procollagen secretions in UVB-irradiated human dermal fibroblasts, downregulated phosphorylation of MAPK-related signaling molecules)

Neuroprotective in cerebral ischemia/reperfusion injury. Anti-Alzheimer’s agent, ameliorated neurobehavioural and neuropathological alteration in mice induced by Aluminum trichloride (AlCl3) and D-galactose. Myrcene alone and in combination with donepezil may serve as a potential candidate for the treatment of Alzheimer's disease (via enhancing synaptic plasticity and cholinergic activity, as well as reducing oxidative damage, neuroinflammation, Aβ1-42 aggregations, and histopathological damage)

Anti-osteoarthritic, may halt or slow down cartilage destruction and osteoarthritis progression (via anti-inflammatory effects and anti-catabolic effects in human chondrocytes)

Analgesia antagonized by naloxone and yohimbine (via possible opioid-mediated and noradrenergic mechanisms, and anti-inflammatory effects)

Gastroprotective in peptic ulcer diseases in gastric and duodenal mucosa models of damage induced by ethanol, NSAIDs, stress, Helicobacter pylori, ischaemia-reperfusion injury, and cysteamine (via increasing mucosal malondialdehyde level, enhancement of antioxidant enzyme activity, decreased activity of superoxide dismutase (SOD) and increased levels of glutathione peroxidase (GPx), glutathione reductase (GR), and total glutathione in gastric tissue)

Anti-invasive effects on breast cancer cells (via downregulation of NF-κB-mediated MMP-9 expression)

Last reviewed by Dr. Abraham Benavides M.D., 04-29-2022

Cannabis Strains High in Myrcene

Pure Kush, Blue Dream, Ace of Spades, Super Bud, Jack Herer

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