Microbiome Research Dashboard
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CannaKeys has 50 studies associated with Microbiome.
Here is a small sampling of Microbiome studies by title:
- Almond Consumption for 8 Weeks Altered Host and Microbial Metabolism in Comparison to a Control Snack in Young Adults
- The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism
- Interplay of gut microbiome, fatty acids, and the endocannabinoid system in regulating development, progression, immunomodulation, and chemoresistance of cancer
- Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
- Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint
Components of the Microbiome Research Dashboard
- Top medical conditions associated with Microbiome
- Proven effects in clinical trials for Microbiome
- Receptors associated with Microbiome
- Individual study details for Microbiome
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Overview - Microbiome
Description of Microbiome
The “human superorganism” concept is often used to describe the microbiome. The human superorganism consists of the human body (the host) and the wide variety of microbial organisms (e.g., viruses, bacteria, fungi) that live within the body and on the skin's surface.
Some microbial members of the “superorganism” are disruptive intruders, such as dermatophytes or fungi that cause onychomycosis (foot and nail fungus). In contrast, others are beneficial organisms called probiotics (e.g., Acidophilus, Bifidum, Akkermansia muciniphila). Most fermented foods such as sauerkraut, kimchi, kefir, and yogurt naturally contain an abundance of probiotic cultures.
The gut contains all components of the classical ECS (i.e., CB1, CB2, AEA, 2-AG, FAAH, MAGL) and, as such, is involved in regulating gut motility, permeability, and inflammatory processes, the connection between the microbiome, probiotics, and components of the endocannabinoid system (ECS) is only beginning to be better understood. However, early data suggest a complex interplay between the ECS and the microbiome that may be individually targeted to induce several health-related effects using diet, nutrition, beneficial bacteria, and cannabinoid-based therapeutics, thus revealing novel opportunities for clinical practice.
Other Names:
MicrobiomeGut microbiome, Microbiota, Probiotics, Metagenome of the microbiota, Microbial biome, Microorganisms existing in the human body, Community of microorganisms, Endomicrobiome
Microbiome Properties and Effects
Cross-talk between ECS and microbiota may be beneficial in:
- Stress resilience (R. Srivastava et al., 2022)
- Cancer progression (S. Nandi et al., 2022)
- Establishing gut homeostasis (H. Cuddihey et al., 2022)
- Treating diverse veterinary conditions (A. Moriello et al., 2022)
- Obesity and related disorders (J. Sihag et al., 2022; S. Tagliamonte et al., 2021)
- Modulate food intake and energy metabolism (M. Shen et al., 2022)
- Regulate inflammation and pain (K. Rea et al., 2021)
- People living with HIV (N. Wilson et al., 2021)
- Acute Respiratory Distress Syndrome (M. Sultan et al., 2021)
- Targeting the ECS with probiotics may improve gut health (J. Jansma et al., 2021)
- Alzheimer's disease (T. Bisogno et al., 2021)
- Treating of anhedonia and amotivation (A. Minichino et al., 2021)
- A. muciniphila increases CB2 expression and improves metabolic outcomes (R. Khan et al., 2021)
Therapeutic Synergies may harnessed by modulating ECS-tone, microbiota, and probiotics:
- Gut microbiome modulate endocannabinoidome signaling (C. Manca et al., 2020)
- Increased intestinal ECS-tone is associated with obesity (Giulio G. Muccioli et al., 2010)
- Obese and diabetic animals have a 2.5-fold increase in CB1 mRNA expression (Giulio G. Muccioli et al., 2010)
- The use of prebiotic or CB1 antagonism decreased intestinal ECS-tone (Giulio G. Muccioli et al., 2010)
- Restoring proper ECS-tone may reduce gut permeability, low-grade inflammation and obesity (Giulio G. Muccioli et al., 2010)
- Administration of L. acidophilus increased CB2 expression (Giulio G. Muccioli et al., 2010)
Additional Therapeutic Synergies may be associated with:
- Vitamin D (H. Hussein et al., 2022)
- Mediterranean diet (S. Tagliamonte et al., 2021)
- L. Acidophilus, Bifidum, Akkermansia muciniphila
Microbiome Receptor Binding
N/A
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
