JWH-x Synthetic Cannabinoids Cannabinoid Research

JWH-x Synthetic Cannabinoids Research Dashboard


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CannaKeys has 146 studies associated with JWH-x Synthetic Cannabinoids.

Here is a small sampling of JWH-x Synthetic Cannabinoids studies by title:

Components of the JWH-x Synthetic Cannabinoids Research Dashboard

  • Top medical conditions associated with JWH-x Synthetic Cannabinoids
  • Proven effects in clinical trials for JWH-x Synthetic Cannabinoids
  • Receptors associated with JWH-x Synthetic Cannabinoids
  • Individual study details for JWH-x Synthetic Cannabinoids

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Overview - JWH-x Synthetic Cannabinoids

Description of JWH-x Synthetic Cannabinoids

The JWH group of compounds is named after the organic chemist John William Huffman (1932–2022). Huffman and his team have developed over 400 synthetic cannabinoid compounds most of which are used to study the endocannabinoid system (ECS) and its potential for medicinal application. However, members of the JWH series contain a number of compounds that have been used to produce "synthetic cannabinoids" such as "Spice", or "K2," which have been implemented in a number of well publicized overdoses and fatalities. As such, many of these compounds are banned in a number of countries such as China, Australia, or Ireland.

Due to their clinical relevance we focus here on two members of the JWH family i.e., JWH-018 and JWH-133.

Other members of this group that have been researched in the context of potential medical applications include: JWH-122 (full agonist at CB1 and CB2), which will also be listed in the primary and related study list accordingly.

Other Names:

JWH Family Synthetic Cannabinoids


Molecular Formula: C24H23NO

IUPAC Name: naphthalen-1-yl-(1-pentylindol-3-yl)methanone


Molecular Formula: C22H32O

IUPAC Name: (6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene


JWH-x Synthetic Cannabinoids Properties and Effects

JWH-018 may: 

  • Adversely affect male reproductive potential and testis histopathology (D. Mutluay et al., 2022)

  • Induce psychosis (Susanna Every-Palmer, 2011; E. Theunissen et al., 2021)

  • Induce anti-epileptic activities in a animal model of Dravet syndrome (A. Griffin et al. 2020)

  • Increase heart rate, impaired critical tracking and memory (E. Theunissen et al., 2019)

  • Induce seizure activities (O. Malyshevskaya et al., 2017)

  • Produce hypothermia (S. Banister et al., 2015)

  • Precipitate psychosis in vulnerable individuals (S. Every-Palmer 2011)

  • Result in dependence (U. Zimmermann et al., 2009)

JWH-133 may: 

  • Increases Ectopic Ovarian Tumor Growth (H. Blanton et al., 2022)

  • Induce apoptosis in gliomas (M. Falasca et al., 2021)

  • Reduce uterine ischemia/reperfusion-induced damage (D. Kirmizi et al., 2021)

  • Increase cerebral blood flow with potential relevance to diabetes (L. Van Hove et al., 2021)

  • Promotes the first wave of in vitro spermatogenesis (L. Dumont et al., 2021)

  • Induce seizure activity (Qiong Wu et al, 2020)

  • Reduce signs and symptoms of sepsis (Murat Çakır et al., 2020)

  • Reduce pro-inflammatory cytokines (He-Kai Shi et al., 2020)

  • Have therapeutic potential for Substance Use Disorders (Ewa Galaj et al., 2019)

  • Anti-inflammatory in lupus erythematosus and rheumatoid arthritis (J. Henriquez et al., 2019)

  • Have acute analgesic effects on virus infection-induced neuropathic pain (W. Sheng et al. 2019)

  • Protect neurons against beta-amyloid peptides with relevance to Alzheimer's (Jingfu Zhao et al., 2020)

  • Alleviated RSV-related lung pathology in the test animals (A. Tahamtan et al., 2018)

  • Reduce neuropathy associated with type 2 diabetes (C. McDonnell et al., 2017)

  • Reduce angiogenesis and inflammation associated with psoriasis (A. Norooznezhad et al., 2017)

  • Reduce pulmonary fibrosis (Qiang Fu et al., 2017)

  • Induce toxic effects on neuroblastoma cells (J. Wojcieszak et al., 2016)

  • Reduce inflammation-induced liver injury (Sunil Tomar et al., 2015)

  • Inhibit inflammation in an animal model of rheumatoid arthritis (S. Fukuda et al., 2014)

  • Decrease HIV-1 reverse transcriptase activity (S. Ramirez et al., 2013)

  • Induce inhibit non-small lung cancer cells (B. Vidinský et al., 2012)

  • Inhibit lung cancer metastasis (A. Preet et al., 2012)

  • Prevent the development of skin and lung fibrosis (A. Servettaz et al., 2010)

  • Reduce breast cancer (Z. Qamri et al., 2009; M. Caffarel et al., 2010)

  • Induce cardio protective effects (F. Montecucco et al., 2009)

  • Induce apoptosis in thyroid carcinoma (Y. Shi et al., 2008)

  • Reduce inflammation in autoimmune uveoretinitis (Heping Xu et al., 2007)

  • Antitussive (H. Patel et al., 2003)

  • Inhibit malignant tumors (C. Sánchez et al., 2001; M. Casanova et al., 2003)

  • Ameliorate tremors and spasticity in an animal model of MS (D. Baker et al., 2000)

JWH-x Synthetic Cannabinoids Receptor Binding

Endocannabinoid System and JWH-018: 

  • CB1 full agonist with a Ki of ~9nM (M. Aung et al., 2000)

  • CB2 full agonist with a Ki of ~3nM (M. Aung et al., 2000)

Endocannabinoidome (eCBome) and JWH-018: 

  • Increases 5-HT2A/2C receptor function in the brain (J. Elmore et al., 2018)

Endocannabinoid System and JWH-133: 

  • CB1 weak agonist with a Ki ~677nM (J. W. Hoffman et al., 1999)

  • CB2 full agonist with a Ki ~3nM (J. W. Hoffman et al., 1999)

Endocannabinoidome (eCBome) and JWH-133:


Ki legend:

  • Full/strong agonist Ki ~1-9nM

  • Moderate agonist Ki ~10-99nM

  • Weak agonist Ki ~100-999nM

  • Very weak agonist Ki ~1,000-up nM

(The reader is reminded that a smaller Ki is associated with the strongest effects.)

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.