Humulene – Terpenes and Cannabinoid Research

Humulene Research Dashboard

18

Primary Studies

7

Related Studies

25

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

5

Animal studies

11

Laboratory studies

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CannaKeys has 25 studies associated with Humulene.

Here is a small sampling of Humulene studies by title:


Components of the Humulene Research Dashboard

  • Top medical conditions associated with Humulene
  • Proven effects in clinical trials for Humulene
  • Receptors associated with Humulene
  • Individual study details for Humulene

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Overview - Humulene

Humulene

Humulene is a sesquiterpene that, while relatively common, is often found in low concentrations. As its name suggests, it provides an earthy, humus-like aroma.

Humulene has properties that are anti-inflammatory, anti-asthmatic, antibacterial, analgesic, and some anticancer activity.

Description of Humulene and Cautions

Humulene appears as a pale liquid with colors ranging between yellow, green, and clear. In its concentrated form it may cause irritation to skin, eye, and mucous membranes including the respiratory tract.
–PubChem

Scent Description

Earthy, woodsy, spicy

Natural Sources

Hops, Basil, black pepper, ginseng

Summary of Humulene Effects

Anti-inflammatory and antioxidant effects (via preventing both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation, eosinophil migration, reduced the production of prostaglandin E(2) (PGE(2)), as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) expression, inhibiting histamine release and NF-κB activation, AP-1, and stimulating antioxidants)

Anti-asthmatic and lung protective effects in murine model of airways allergic inflammation (via reducing eosinophil migration into the BALF and lung tissue, modulation of Th1/Th2 balance, decreased mucus production, inhibition of IL-5, CCL11 and LTB4 levels and P-selectin expression, probably by inhibiting the activation of the transcription factors NF-κB and AP-1)

Antibacterial against enterotoxigenic Bacteroides fragilis, which causes inflammatory bowel disease (via antibiofilm effects, significantly reduced the expression of bmeB1 and bmeB3 genes involved in multidrug resistance)

Analgesic (via COX inhibition through a reduction of the PGE2 pathway, cannabimimetic actions, and perhaps other anti-inflammatory and non-opioid mechanisms)

Anticancer, antitumor activity and chemo synergistic, inhibits the proliferation of hepatocellular carcinoma (HCC) cells, ovarian cancer cells, lymphoblast cancer cells, breast cancer cells, and colon cancer cells (via induction of intrinsic apoptotic pathways both in vitro and in vivo through inhibiting Akt activation, GSH depletion and ROS production in tumor cells, potentiates paclitaxel passage and activity, synergy with doxorubicin in sensitive and partly resistant lines but not DOX-resistant lines)

Cannabimimemetic and cannabis synergistic (via cannabinoid and adenosine receptors)

Gastric mucosa protective, may attenuate HCl/ethanol-induced gastritis (via inhibiting histamine release and NF-κB activation and stimulating antioxidants and mucosal protective factors, particularly Muc5ac and Muc6)

Last reviewed by Dr. Abraham Benavides M.D., 04-28-2022

Cannabis Strains High in Humulene

Jack Herer, Chemdawg, Original Glue, Death Star, Sour Diesel

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.