Humulene – Terpenes and Cannabinoid Research

Humulene Research Dashboard


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CannaKeys has 29 studies associated with Humulene.

Here is a small sampling of Humulene studies by title:

Components of the Humulene Research Dashboard

  • Top medical conditions associated with Humulene
  • Proven effects in clinical trials for Humulene
  • Receptors associated with Humulene
  • Individual study details for Humulene

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Overview - Humulene

What is Humulene?

Humulene is a sesquiterpene that, while relatively common, is often found in low concentrations.

As its name suggests, it provides an earthy, humus-like aroma.

Humulene has properties that are anti-inflammatory, anti-asthmatic, antibacterial, analgesic, and have some anticancer activity.

Is Humulene safe?

Humulene appears as a pale liquid with colors ranging between yellow, green, and clear. Its concentrated form may irritate skin, eyes, and mucous membranes, including the respiratory tract.

Other Names

IUPAC Name: (1E,4E,8E)-2,6,6,9-tetramethylcycloundeca-1,4,8-triene


Scent Description

Earthy, woodsy, spicy

Natural Sources

Hops, Basil, black pepper, ginseng

Cannabis Strains High in Humulene

Jack Herer, Chemdawg, Original Glue, Death Star, Sour Diesel

Humulene Properties and Effects

Humulene is associated with the following properties and effects:

  1. Anti-cancer

    1. Inhibits cell proliferation (H. Chen et al., 2019)

    2. Induces Apoptosis (H. Chen et al., 2019)

  2. Anti-inflammatory (A. Rogerio et al., 2009)

  3. Anti-microbial

    1. Anti-bacterial (against B. fragilis) (Hye-In Jang et al., 2020)

  4. Gastro-protective (Dahee Yeo et al., 2021)

Anti-inflammatory and antioxidant effects (via preventing both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation, eosinophil migration, reduced the production of prostaglandin E(2) [PGE(2)], as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) expression, inhibiting histamine release and NF-κB activation, AP-1, and stimulating antioxidants)

Anti-asthmatic and lung protective effects in a murine model of airways allergic inflammation (via reducing eosinophil migration into the BALF and lung tissue, modulation of Th1/Th2 balance, decreased mucus production, inhibition of IL-5, CCL11, and LTB4 levels and P-selectin expression, probably by inhibiting the activation of the transcription factors NF-κB and AP-1)

Antibacterial against enterotoxigenic Bacteroides fragilis, which causes inflammatory bowel disease (via antibiofilm effects, significantly reduced the expression of bmeB1 and bmeB3 genes involved in multidrug resistance)

Analgesic (via COX inhibition through a reduction of the PGE2 pathway, cannabimimetic actions, and perhaps other anti-inflammatory and non-opioid mechanisms)

Anticancer, antitumor activity, and chemo synergistic inhibits the proliferation of hepatocellular carcinoma (HCC) cells, ovarian cancer cells, lymphoblast cancer cells, breast cancer cells, and colon cancer cells (via induction of intrinsic apoptotic pathways both in vitro and in vivo through inhibiting Akt activation, GSH depletion and ROS production in tumor cells, potentiates paclitaxel passage and activity, synergy with doxorubicin in sensitive and partly resistant lines but not DOX-resistant lines)

Cannabimimemetic and cannabis synergistic (via cannabinoid and adenosine receptors)

Gastric mucosa protection may attenuate HCl/ethanol-induced gastritis (via inhibiting histamine release and NF-κB activation and stimulating antioxidants and mucosal protective factors, particularly Muc5ac and Muc6)

Last reviewed by Dr. Abraham Benavides, M.D., 04-28-2022

Humulene Receptor Binding

Endocannabinoid System (ECS) and Humulene:


Endocannabinoidome (eCBome) and Humulene:

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