Eucalyptol – Terpenes and Cannabinoid Research

Eucalyptol Research Dashboard


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CannaKeys has 61 studies associated with Eucalyptol.

Here is a small sampling of Eucalyptol studies by title:

Components of the Eucalyptol Research Dashboard

  • Top medical conditions associated with Eucalyptol
  • Proven effects in clinical trials for Eucalyptol
  • Receptors associated with Eucalyptol
  • Individual study details for Eucalyptol

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Overview - Eucalyptol

What is Eucalyptol?

Eucalyptol, also known as Cineole, is named after the tree in which it is found to be most abundant, the eucalyptus tree.

It is used in insect repellents and insecticides and frequently in the cosmetic (mouthwash) and chemical industries (e.g., cleaning agents) as a flavor and scenting agent.

It has a mint-like cooling scent.

Eucalyptol has properties that are anti-inflammatory, antioxidant, anxiolytic, cough suppressant, mucolytic, bronchiolitis, choleretic, anticancer, antiseptic, and antimicrobial.

Is Eucalyptol safe?

Eucalyptol is a colorless liquid that has been given GRAS (generally recognized as safe) status though the isolated form can cause skin irritation and gastrointestinal upset if ingested.

Other Names

IUPAC Name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane


Scent Description

Minty, cooling, earthy

Natural Sources

Eucalyptus, tea tree oil, rosemary

Cannabis Strains High in Eucalyptol

Super Silver Haze, Girl Scout Cookies, Bubba Kush

Eucalyptol Properties and Effects

Eucalyptol may induce the following properties or effects:

  1. Analgesic

    1. Anti-inflammatory pain (A. Horváth et al., 2022)

  2.  Anti-asthmatic (H. Worth et al., 2012)

  3. Anti-cancer

    1. Anti-metastatic (in skin cancer cells) (A. Rahaman et al., 2022)

  4. Anti-microbial 

    1. Anti-bacterial (against Klebsiella pneumoniae) (Chew-Li Moo et al., 2021)

    2. Anti-viral (SARS-CoV-2) (M. Valussi et al., 2021)

  5. Anti-oxidant (G. Xu et al., 2022)

  6. Anti-tussive (reduces the frequency of coughs) (J. Fischer et al., 2013)

  7. Bronchodilator (L. Joy Juergens et al., 2020)

  8. Lung Protector (protects against acute injuries from cigarette smoke) (F. de Lima Gondim et al., 2019)

  9. Neuroprotective (C. Meng et al., 2021)

Reduces phlegm, cough, airway inflammation, rhinosinusitis, and nasal congestion (via enhanced ciliary clearing, mucolysis, anti-inflammatory, and bronchodilation)

Produces analgesia centrally and peripherally (via μ-opioid receptor activity, antioxidant, and anti-inflammatory effects)

May reduce anxiety in preoperative humans and anxiety/depression symptoms in mice (via GABA receptors)

Lung protective against inflammation and infectious causes potentially including COVID-19, in COPD, bronchitis, and in rats exposed to short-term cigarette smoke (via bronchodilatory, binding to COVID-19 proteinase, antioxidant, anti-inflammatory effects through selective downregulation of the PRR pathways, including PRR receptors (TREM-1 and NLRP3) and common downstream signaling cascade partners (NF-κB, MAPKs, MKP-1)

Neuroprotective in early brain ischemia in rats with SAH and stroke-induced ischemia (via reduced neuronal apoptosis, microglial activation, oxidative stress, and TRPC6/CREB pathways)

Potential role in preventing Alzheimer’s disease (via reduced oligomerization of amyloid beta peptide, antioxidant, and less iron-induced cell death)

It may be protective against certain cancers such as leukemia, ovarian, and skin cancer metastasis (via increased cytotoxicity and the PI3K/Akt/mTOR Pathway)

Antimicrobial effects against S. aureus, E. coli, E. faecalis, P. aeruginosa, C. albicans, and carbapenemase-producing Klebsiella pneumonia (via QS inhibition, anti-biofilm actions, and disruption of microbial cell walls and membranes)

In atherosclerotic rat models, it prevents the formation of atheromatous lesions, glycation, oxidative stress, and inflammatory markers, as well as improves glycemia, insulin resistance, lipid profile, renal function, and activity of glyoxalase-1 (GLO-I) (via reduction of glycation, oxidative stress, and inflammatory mediators)

Last reviewed by Dr. Abraham Benavides, M.D., 04-21-2022

Eucalyptol Receptor Binding

Endocannabinoid System (ECS) and Eucalyptol:

  1. CB1 (agonist) (N. Raz et al., 2023)

Endocannabinoidome (eCBome) and Eucalyptol:

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.