Eucalyptol – Terpenes and Cannabinoid Research

Eucalyptol Research Dashboard

42

Primary Studies

16

Related Studies

58

Total Studies

Clinical Studies

0

Clinical Meta-analyses

7

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

11

Animal studies

19

Laboratory studies

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CannaKeys has 58 studies associated with Eucalyptol.

Here is a small sampling of Eucalyptol studies by title:


Components of the Eucalyptol Research Dashboard

  • Top medical conditions associated with Eucalyptol
  • Proven effects in clinical trials for Eucalyptol
  • Receptors associated with Eucalyptol
  • Individual study details for Eucalyptol

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Overview - Eucalyptol

Eucalyptol

Eucalyptol, also known as Cineole, is named after the tree in which it is found to be most abundant, the eucalyptus tree. It is used in insect repellents and insecticides, and frequently used in the cosmetic (mouthwash) and chemical industries (e.g. cleaning agents) as a flavor and scenting agent. It has a mint-like cooling scent.

Eucalyptol has properties that are anti-inflammatory, antioxidant, anxiolytic, cough suppressant, mucolytic, broncholytic, choleretic, anticancer, antiseptic, and antimicrobial.

Description of Eucalyptol and Cautions

Eucalyptol is a colorless liquid that has been given GRAS (generally recognized as safe) status though the isolated form can cause skin irritation and gastrointestinal upset if ingested.–PubChem

Scent Description

Minty, cooling, earthy

Natural Sources

Eucalyptus, tea tree oil, rosemary

Summary of Eucalyptol Effects

Reduces phlegm, cough, airway inflammation, rhinosinusitis, and nasal congestion (via enhanced ciliary clearing, mucolysis, anti-inflammatory, and bronchodilation)

Produces analgesia centrally and peripherally (via μ-opioid receptor activity, antioxidant, and anti-inflammatory effects)

May reduce anxiety in preoperative humans and anxiety/depression symptoms in mice (via GABA receptors)

Lung protective against inflammation, infectious causes potentially including COVID-19, in COPD, bronchitis, and in rats exposed to short-term cigarette smoke (via bronchodilatory, binding to COVID-19 proteinase, antioxidant, anti-inflammatory effects through selective downregulation of the PRR pathways, including PRR receptors (TREM-1 and NLRP3) and common downstream signaling cascade partners (NF-κB, MAPKs, MKP-1))

Neuroprotective in early brain ischemia in rats with SAH and stroke-induced ischemia (via reduced neuronal apoptosis, microglial activation, oxidative stress, and TRPC6/CREB pathways)

Potential role in preventing Alzheimer’s disease (via reduced oligomerization of amyloid beta peptide, antioxidant, and less iron-induced cell death)

May be protective against certain cancers such as leukemia, ovarian, and skin cancer metastasis (via increased cytotoxicity and the PI3K/Akt/mTOR Pathway)

Antimicrobial effects against S. aureus, E. coli, E. faecalis, P. aeruginosa, C. albicans, and carbepenemase-producing Klebsiella pneumonia (via QS inhibition, anti-biofilm actions, and disruption of microbial cell walls and membranes)

In atherosclerotic rat models, prevents formation of atheromatous lesions, glycation, oxidative stress, and inflammatory markers as well as improves glycemia, insulin resistance, lipid profile, renal function, and activity of glyoxalase-1 (GLO-I) (via reduction of glycation, oxidative stress, and inflammatory mediators)

Cannabis Strains High in Eucalyptol

Super Silver Haze, Girl Scout Cookies, Bubba Kush

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.