DOSING DETAILS   

Study Dosing Objective:  Effective Dose

Established Protocol:  Effective dose

Route of Administration: 

Cannabinoid Ratio:  (CBD : Pharma CBD)   1 : 1    

Dosage Form:  CBD Supplement (1): 993.50mg/g 99.35% CBD Supplement (2): 704.30mg/g 70.43%

Starting Dose:  Twin 1: CBD supplement at 4 mg/kg/day Twin 2: CBD supplement at 2 mg/kg/day

Titration:  Twin 2: titrated up weekly by 2 mg/kg/day

Maximum Dose:  Twin 1: 400 mg/day Twin 2: 600 mg/day

Clinical Relevance:  Monozygotic twins achieved seizure suppression with CBD supplements containing different ingredients.

Additional Notes:  Parallel Dose Comparison, Dose Titration, Dose Escalation

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