RELATED STUDY

Non-THC Cannabinoids Inhibit Prostate Carcinoma Growth In Vitro And In Vivo: Pro-apoptotic Effects And Underlying Mechanisms

Key Findings:  Results demonstrated that extract of cannabis (i.e. CBC, CBD, CBG, CBN, CBDA, CBGA, CBDV, CBGV, THC, THCA, THCV, THCVA) but especially CBD were able to significantly inhibit prostate carcinoma growth, retard proliferation and cause apoptosis via a combination of cannabinoid receptor-independent, cellular and molecular mechanisms. Furthermore, CBD was observed to produce apoptosis alone and created a treatment synergy with bicalutamide and docetaxel commonly used chemotherapeutic agents. Effects were produced via TRPM8 (via partial CBD antagonism). These findings suggest that Cannabis extracts fortified with CBD might provide the basis for new therapies against prostate carcinoma, either as stand-alone treatment or in addition to the commonly used chemotherapeutic drugs.