Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia.

Key Findings:  Through these direct mechanisms or through indirect mechanisms involving GABA or glutamate neurons, cannabinoids may interact with dopaminergic transmission in the basal ganglia and this is likely to have important effects on dopamine-related functions in these structures (i.e. control of movement) and, particularly, on different pathologies affecting these processes, in particular, Parkinson's disease, but also dyskinesia, dystonia and other pathological conditions.

Type of Study:  Meta-analysis

Study Result:  Positive

Cannabinoids Studied:  Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Cannabinoid (unspecified), Other Related Compounds

Phytocannabinoid Source:  Not Applicable

Form of Administration:  Not Applicable

Receptors Studied:  CB1, CB2, TRPV1, PPAR - Alpha, PPAR - Gamma

Ligands Studied:  Dopamine, GABA, Glutamate

Study Location(s):  Spain

Year of Pub:  2016

Link to study