PRIMARY STUDY
Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease
Key Findings: Downregulation of CB2 receptors has been reported in the brains of PD patients. Therefore, both the activation and the upregulation of the CB2 receptors are believed to protect against the neurodegenerative changes in PD. The present study suggests that ß-Caryophyllene (BCP) has the potential therapeutic efficacy to elicit significant neuroprotection by its anti-inflammatory and antioxidant activities mediated by activation of the CB2 receptors. AM630 diminished the beneficial effects of BCP.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Australia, Italy, United Arab Emirates
Year of Pub: 2016
Cannabinoids Studied: AM-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Injection
Dosage Form: β-caryophyllene diluted in olive oil
Dosing Regimen: β-caryophyllene 50 mg/kg i.p. once daily 30 min prior to rotenone (ROT) administration (with or without AM630, a CB2 receptor antagonist)
Treatment Duration: 4 weeks
Clinical Relevance: β-caryophyllene (BCP) has the potential therapeutic efficacy to elicit significant neuroprotection by its anti-inflammatory and antioxidant activities mediated by activation of the CB2 receptors
Citation: Javed H, et al. Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease. Front Neurosci. 2016; 10:321. doi: 10.3389/fnins.2016.00321
Authors: Javed H, Azimullah S, Haque ME, Ojha SK
