Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.

Key Findings:  The study demonstrated up-regulation of the CB1 receptor in direct response to neuronal injury in a human PD cell culture model, and a direct neuronal protective effect of Δ⁹-THC that may be mediated through PPARγ activation.

Type of Study:  Laboratory Study

Study Result:  Positive

Cannabinoids Studied:  Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids

Phytocannabinoid Source:  Not Applicable

Chemotype:  Chemotype I

Form of Administration:  Not Applicable

Receptors Studied:  PPAR - Gamma

Study Location(s):  United Kingdom

Year of Pub:  2012

Link to study