Key Findings:  The study demonstrated up-regulation of the CB1 receptor in direct response to neuronal injury in a human PD cell culture model, and a direct neuronal protective effect of Δ⁹-THC that may be mediated through PPARγ activation. The neuroprotective effect was not reproduced by WIN55,212-2 or AM251.
Type of Study:  Laboratory Study
Study Result:  Positive
Study Location(s):  United Kingdom
Year of Pub:  2012
Cannabinoids Studied:  Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids
Phytocannabinoid Source:  Not Applicable
Chemotype:  Chemotype I
Receptors Studied:  PPAR - Gamma