PRIMARY STUDY
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.
Key Findings: The study demonstrated up-regulation of the CB1 receptor in direct response to neuronal injury in a human PD cell culture model, and a direct neuronal protective effect of Δ⁹-THC that may be mediated through PPARγ activation. The neuroprotective effect was not reproduced by WIN55,212-2 or AM251.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2012
Cannabinoids Studied: Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Chemotype: Chemotype I
Receptors Studied: PPAR - Gamma
Route of Administration: In vitro
Citation: Carroll CB, et al. Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease. Neuropathol Appl Neurobiol. 2012; 38:535-47. doi: 10.1111/j.1365-2990.2011.01248.x
Authors: Carroll CB, Zeissler ML, Hanemann CO, Zajicek JP
