DOSING DETAILS   

Study Dosing Objective:  Other

Established Protocol:  Adverse effects

Route of Administration: 

Cannabinoid Ratio:  (CBD)   0    

Dosing Regimen:  CBD 10 mg/kg/day

Starting Dose:  20 mg/kg/day

Titration:  A gradual decrease of the cannabidiol from 20 mg/kg/day (450 mg BID) to 15 mg/kg/day (350 mg BID)

Clinical Relevance:  A case report of a patient on long-term cannabidiol therapy with persistent diarrhea, abdominal pain, weight loss, and esophageal eosinophilia likely due to cannabidiol. Symptoms improved with dose adjustments over 2 weeks.

Adverse Events:  persistent diarrhea, abdominal pain, peripheral eosinophilia, esophageal eosinophilia, and weight loss

Additional Notes:  Dose Titration

Citation: