PRIMARY STUDY

AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner

Key Findings:  Using hippocampal neurons and mouse models of pain and gastric motility, this study concludes that AM841 via CB1 receptors significantly reduced gastric motility. The effect was more pronounced under stress conditions. This may provide future therapeutic targets for disorders of gastrointestinal mobility like colitis and irritable bowel syndrome.