Key Findings:  The authors highlight the role the eCBome plays in the microbiota-gut-brain axis and its association with affective and cognitive functions and in their pathological alterations in neuropsychiatric disorders. In addition, the review focuses on eCBome-based drugs beyond that of THC including CBD, which possess a wide therapeutic window.
Type of Study:  Meta-analysis
Study Result:  Positive
Research Location(s):  Italy
Year of Pub:  2020
Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), Microbiome
Phytocannabinoid Source:  Unspecified
Receptors Studied:  CB1, CB2
Citation:  Di Marzo V. The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders . Dialogues Clin Neurosci. 2020; 22:259-269. doi: 10.31887/DCNS.2020.22.3/vdimarzo
Authors:  Di Marzo V