A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment

Key Findings:  This review concludes that zebrafish may prove a useful model for cannabinoid exposure studies. Also emphasized is the need for research into the full spectrum of cannabinoids, beyond the better-known cannabidiol (CBD)and ∆9-tetrahydrocannabinol (THC), as well as studies looking at the mechanism of cannabinoids and the endocannabinoid system and their role in neurological disorders.

Type of Study:  Meta-analysis

Study Result:  Positive

Study Location(s):  Italy

Year of Pub:  2022

Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), CP-x Synthetic Cannabinoids, AM-x Synthetic Cannabinoids, JWH-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), Cannabinoid (unspecified), Endocannabinoid (unspecified), Pharma THC, Pharma CBD, Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV)

Phytocannabinoid Source:  Unspecified

Receptors Studied:  CB1, CB2, GPCR 18, GPCR 55, TRPs

Ligands Studied:  GABA, Oxytocin, Serotonin