The Autism–Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System

Key Findings:  This review explores the role of the endocannabinoid system in early neurobiological development and modulation of neural circuits, and how alterations could be implicated in Autism spectrum disorder (ASD), and similar neurodivergent conditions like schizophrenia and psychosis. Also reviewed are potential therapeutic targets in the treatment of these disorders.

Type of Study:  Meta-analysis

Study Result:  Inconclusive

Study Location(s):  Italy, United Kingdom

Year of Pub:  2022

Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Cannabinoid (unspecified), Endocannabinoid (unspecified)

Phytocannabinoid Source:  Unspecified

Chemotype:  Chemotype I, Chemotype III

Receptors Studied:  CB1, CB2

Ligands Studied:  Dopamine, GABA, Glutamate, Serotonin