RELATED STUDY
Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders
Key Findings: This extensive review covers the existing evidence of the distribution of CB2 in several brain areas and different brain cells like neurons and glial cells, and notes that CB2 may directly regulate the immune system and the neuronal circuits, and regulate inflammation, mood, and cognitive functions.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Spain, Sweden
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, JWH-x Synthetic Cannabinoids, HU-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Virodhamine (O-AEA), Endocannabinoid (unspecified), Lysophosphatidylinositol (LPI), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, TRPV1, PPAR - Gamma
Ligands Studied: Dopamine, GABA, Norepinephrine, Serotonin, Glucocorticoid
Citation: Morcuende A, et al. Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders. Front Psychiatry. 2022; 13:866052. doi: 10.3389/fpsyt.2022.866052
Authors: Morcuende A, García-Gutiérrez MS, Tambaro S, Nieto E, Manzanares J, Femenia T
