Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders

Key Findings:  This extensive review covers the existing evidence of the distribution of CB2 in several brain areas and different brain cells like neurons and glial cells, and notes that CB2 may directly regulate the immune system and the neuronal circuits, and regulate inflammation, mood, and cognitive functions.

Type of Study:  Meta-analysis

Study Result:  Positive

Study Location(s):  Spain, Sweden

Year of Pub:  2022

Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, JWH-x Synthetic Cannabinoids, HU-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Virodhamine (O-AEA), Endocannabinoid (unspecified), Lysophosphatidylinositol (LPI), Palmitoylethanolamide (PEA)

Phytocannabinoid Source:  Not Applicable

Receptors Studied:  CB1, CB2, TRPV1, PPAR - Gamma

Ligands Studied:  Dopamine, GABA, Norepinephrine, Serotonin, Glucocorticoid