Key Findings:  This study found that cannabidivarin (CBDV) targets neurotypical and autistic adult brains in mostly the same way, but the individual response to CBDV in the autistic brains was more variable depending on initial glutamate and glutamine levels. This supports further understanding of how CBDV affects the brain, but not necessarily on how it affects the autistic brain.
Type of Study:  Double Blind Clinical Trial
Study Sample Size:  34
Study Result:  Inconclusive
Research Location(s):  United Kingdom, United States
Year of Pub:  2019
Cannabinoids Studied:  Cannabidivarin (CBDV)
Phytocannabinoid Source:  Not Applicable
Receptors Studied:  TRPA1, TRPV1, TRPV2
Ligands Studied:  GABA, Glutamate
Dosage: CBDV (600 mg)
Route of Administration:  Oral (Ingestion)
Citation:  Pretzsch CM, et al. Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy. Transl Psychiatry. 2019; 9:313. doi: 10.1038/s41398-019-0654-8
Authors:  Pretzsch CM, Voinescu B, Lythgoe D, Horder J, Mendez MA, Wichers R, Ajram L, Ivin G, Heasman M, Edden RAE, Williams S, Murphy DGM, Daly E, McAlonan GM