PRIMARY STUDY
Palmitoylethanolamide and Its Biobehavioral Correlates in Autism Spectrum Disorder: A Systematic Review of Human and Animal Evidence
Key Findings: This review of human and animal research on the effects of palmitoylethanolamide (PEA) on several neurobiological processes as well as improvement in language and behavior in Autism spectrum disorders (ASD). PEA also has a role in immunity, inflammation, neuron plasticity, regeneration, and apoptosis possibly through activation of PPAR-α receptors. Its overall safety profile makes PEA a possible therapeutic option for the treatment of ASD.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Italy, United Kingdom
Year of Pub: 2021
Cannabinoids Studied: Endocannabinoid (unspecified), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Receptors Studied: GPCR 55, PPAR - Alpha
Ligands Studied: Glutamate, Pro-inflammatory cytokines
Citation: Colizzi M, et al. Palmitoylethanolamide and Its Biobehavioral Correlates in Autism Spectrum Disorder: A Systematic Review of Human and Animal Evidence. Nutrients. 2021; 13:(unknown pages). doi: 10.3390/nu13041346
Authors: Colizzi M, Bortoletto R, Costa R, Zoccante L
