Key Findings:  This preclinical test found the nanoparticulation of β-caryophyllene, to target the CB2 receptors in the brain, makes it suitable for intranasal administration, which may present therapeutic delivery options in disorders that require CNS penetration, such as neurodegenerative diseases.
Type of Study:  Laboratory Study
Study Result:  Positive
Research Location(s):  Brazil
Year of Pub:  2020
Cannabinoids Studied: 
Phytocannabinoid Source:  Unspecified
Terpenes Studied:  ß-Caryophyllene
Receptors Studied:  CB2
Route of Administration:  Nasal
Citation:  Alberti TB, et al. β-Caryophyllene nanoparticles design and development: Controlled drug delivery of cannabinoid CB2 agonist as a strategic tool towards neurodegeneration. Mater Sci Eng C Mater Biol Appl. 2021; 121:111824. doi: 10.1016/j.msec.2020.111824
Authors:  Alberti TB, Coelho DS, Maraschin M