Key Findings:  Based on finding from their study the authors posit that patients with autosomal dominant polycystic kidney disease have lower levels of endocannabinoids (when compared to healthy people) and that re-establishing endocannabinoid balance (via augmentation of AEA, PEA, and 2-AG levels) may present a novel therapeutic target in this patient population.
Type of Study:  Meta-analysis
Study Sample Size:  202
Study Result:  Positive
Research Location(s):  United States
Year of Pub:  2022
Cannabinoids Studied:  Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Other Related Compounds
Phytocannabinoid Source:  Not Applicable
Citation:  Klawitter J, et al. Endocannabinoid System in Polycystic Kidney Disease. Am J Nephrol. 2022; 53:264-272. doi: 10.1159/000522113
Authors:  Klawitter J, Sempio C, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Christians U, Klawitter J