PRIMARY STUDY
Potential use for chronic pain: Poly(Ethylene Glycol)-Poly(Lactic-Co-Glycolic Acid) nanoparticles enhance the effects of Cannabis-Based terpenes on calcium influx in TRPV1-Expressing cells
Key Findings: Resulting data led the authors to conclude that terpene-encapsulated poly(ethylene glycol)-poly(lactic-co-glycolic acid) nanoparticles (i.e., β-myrcene, β-caryophyllene, and nerolidol) may be novel therapeutics compounds in the treatment of chronic pain.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Spain, United States
Year of Pub: 2022
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene, Myrcene, Nerolidol
Receptors Studied: TRPV1
Route of Administration: In vitro
Citation: El-Hammadi MM, et al. Potential use for chronic pain: Poly(Ethylene Glycol)-Poly(Lactic-Co-Glycolic Acid) nanoparticles enhance the effects of Cannabis-Based terpenes on calcium influx in TRPV1-Expressing cells. Int J Pharm. 2022; 616:121524. doi: 10.1016/j.ijpharm.2022.121524
Authors: El-Hammadi MM, Small-Howard AL, Jansen C, Fernández-Arévalo M, Turner H, Martín-Banderas L
