PRIMARY STUDY

Beta-caryophyllene inhibits cocaine addiction-related behavior by activation of PPARα and PPARγ: repurposing a FDA-approved food additive for cocaine use disorder

Key Findings:  Resulting data showed that BCP reduced, in a dose-dependent fashion, cocaine self-administration, cocaine-conditioned place preference, and cocaine-primed reinstatement of drug seeking but not food self-administration or cocaine-induced hyperactivity in the test animals. Data further attributed these BCP-induced effects to modulation of PPARα and PPARγ and not to CB1, CB2, or GPR55 receptor mechanisms.