PRIMARY STUDY
Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
Key Findings: The results revealed that beta-cayophyllene might have significant and effective anti-cancer and anti-proliferative effects in multiple myeloma cells by activating apoptosis, modulating different molecular pathways, and downregulating the cell cycle.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Italy, Qatar
Year of Pub: 2021
Cannabinoids Studied: AM-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Dosage: Cells were treated with different concentrations of BCP for 24 h
Route of Administration: In vitro
Citation: Mannino F, et al. Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells. Cancers (Basel). 2021; 13:(unknown pages). doi: 10.3390/cancers13225741
Authors: Mannino F, Pallio G, Corsaro R, Minutoli L, Altavilla D, Vermiglio G, Allegra A, Eid AH, Bitto A, Squadrito F, Irrera N
