PRIMARY STUDY

High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain

Key Findings:  Data revealed that weight changes induced by THCV and rimonabant were in part mediated by modulation of GPR55 (notably THCV acted an agonist or an antagonist depending on the assay).