DOSING DETAILS   

Study Dosing Objective:  Effective Dose

Established Protocol:  Effective dose

Route of Administration: 

Cannabinoid Ratio:  (CBD : THC)   4 : 1    

Dosage Form:  Avidekel oil contained 16% CBD and 4% THC. Each oil drop is approximately 0.05 ml, containing about 8 mg CBD and 2 mg THC. Place the oil under the tongue and roll it in their mouth until absorbed

Dosing Regimen:  Patients received either cannabis oil containing 160/40mg/ml CBD/THC or placebo

Starting Dose:  starting dose was 1 drop twice daily before meals

Titration:  gradually increased until the patient felt a satisfactory effect

Maximum Dose:  maximal allowed dose was 20 drops per administration

Treatment Duration:  eight weeks

Clinical Relevance:  CBD-rich cannabis resulted in a significant clinical and quality of life improvement in patients with Crohn's disease but without changes in inflammatory parameters or endoscopic scores.

Adverse Events:  The only symptom that was more common in the extract group was decreased memory

Additional Notes:  Pharmacokinetic Study Data, Parallel Dose Comparison

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