Key Findings:  An oral form of a whole-plant cannabis-based extract containing CBD:THC in a ratio of 20:1 was given to pediatric patients diagnosed with autism spectrum disorder (ASD) dealing with disruptive behaviors. Compared to the placebo group the extract was associated with a significant drop in disruptive behavior (49%). Furthermore, the treatment was well tolerated. The oral administration of plant-derived cannabis extracts is well-tolerated and reduces disruptive behaviors in children with autism spectrum disorder (ASD), according to clinical trial data published in the journal Molecular Autism.
Type of Study:  Double Blind Clinical Trial
Study Sample Size:  150
Study Result:  Positive
Research Location(s):  Israel, United States
Year of Pub:  2021
Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source:  Cannabis Flower derived
Chemotype:  Chemotype III
Sub-Ratio: 20:1 (CBD:THC)
Route of Administration:  Oral (Ingestion)
Citation:  Aran A, et al. Cannabinoid treatment for autism: a proof-of-concept randomized trial. Mol Autism. 2021; 12:6. doi: 10.1186/s13229-021-00420-2
Authors:  Aran A, Harel M, Cassuto H, Polyansky L, Schnapp A, Wattad N, Shmueli D, Golan D, Castellanos FX